Spatial Genomics Scientist

vor 14 Stunden

Basel, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.

That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organization (pRED, we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

360 Labs Initiative at a Glance

The 360 Labs are a new capability that is currently being built up within the Pharmaceutical Research and Early Development organization (pRED. The primary mission of this effort is to provide greater access and support for the use of cutting-edge biomedical research technologies by scientists across our discovery portfolio.

The 360 Labs will deliver core scientific technologies, expertise and enabling activities, as well as facilitate knowledge sharing in close collaboration with our therapeutic areas and functions. Our ambition is to bring to life a thriving workplace environment, where your collaborative mindset is as valued as your professional expertise. Our goal is to act as a highly integrated ecosystem, supporting research and development, working collaboratively, and focused on fostering excellence and sustainability. Together, these efforts will serve to increase the speed, enhance the robustness and improve the sustainability of our exploratory research and early discovery activities.

The Opportunity

The Genomics Technology Platform in the 360 Labs Initiative is seeking an experienced, highly motivated, collaborative, and customer-oriented lab-based scientist who is passionate about using spatial transcriptomics in drug discovery. The successful candidate will have a robust background in molecular biology or biochemistry along with hands-on expertise in the application of 10X Genomics Xenium imaging-based spatial transcriptomics. You will operate at the intersection between the Research Histopathology and Genomics Technology Platforms. You will work with a sense of urgency as a member of a matrix team, collaborating with specialists from each of our therapeutic disease areas and functions to propel drug discovery projects forward, and will also contribute to the ongoing development of the Genomics Technology Platform within the pRED organization.

Your Role and Responsibilities
  • Independently plan, design, and conduct experiments to explore the spatially resolved transcriptome for disease biology and drug mechanism insights, while developing and optimizing both standard and customized spatial transcriptomics workflows using the 10X Genomics Xenium platform, including data quality control and processing;
  • Apply scientific rigor to ensure high-quality FAIR data generation by optimizing newly implemented or developed spatial transcriptomics workflows, collaborate with other laboratory and bioinformatics teams to analyze and interpret spatial transcriptomics data, be accountable for the timely generation of comprehensive project reports and engage with stakeholders to present and discuss findings in a dynamic and flexible manner;
  • Embrace a continuous learning mindset by actively engaging with the scientific literature to stay abreast of emergent technologies/ approaches in the spatial transcriptomics field.
Who you are
  • You hold a PhD degree in Biology, Biochemistry or a related field, with 3-5 years of professional experience, either in an academic setting, or in the pharmaceutical industry / biotech sector;
  • You have practical, hands-on experience in the implementation, optimisation, and execution of both routine and custom-designed assays using the 10X Genomics Xenium spatial transcriptomics platform in a rigorous and reproducible manner. Expertise in other NGS-based spatial transcriptomics methodologies will be considered a plus;
  • You have a proven ability to collaborate within and across matrix teams, including molecular biologists, research histopathologists, and bioinformaticians, to design spatial transcriptomics assays and interpret results.

In addition to your scientific expertise and critical technical skills we are looking for candidates who are:

  • Customer-focused with a drive for growth and a questioning mindset. Skilled in creative problem-solving, organization, and implementing innovative ideas efficiently in a fast-paced research context;
  • Excellent communicators with a high fluency in English, a desire to continuously build a personal network and the ability to thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development.
Your Location

This position is based in Basel.

Our commitment

Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche's largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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