Master project "The basis for developmental robustness against disease in a mouse model for Fib[...]
vor 3 Wochen
Organisation/Company: University of Basel
Department: Department of Biomedicine
Research Field: Biological sciences » Biology
Researcher Profile: Leading Researcher (R4) Positions
Country: Switzerland
Application Deadline: 31 Mar 2025 - 12:00 (Europe/Zurich)
Type of Contract: Not Applicable
Job Status: Not Applicable
Offer Starting Date: 1 Feb 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer DescriptionThe basis for developmental robustness against disease in a mouse model for Fibrodysplasia Ossificans Progressiva.
Developmental Genetics
Department Biomedicine, University of Basel
Embryonic development is a marvel of biological complexity as gene expression, cellular development and differentiation are seamlessly integrated across tissue, organ and the organism as a whole. Despite the susceptibility to molecular and cellular disturbances, an intrinsic robustness within embryos often prevails, shielding developmental processes from genetic perturbations. Our research has unveiled fascinating insights into the molecular basis of developmental robustness and we are now applying this knowledge to explore the underlying mechanisms of developmental robustness in congenital diseases, an emerging field of significant biomedical interest. Fibrodysplasia Ossificans Progressiva (FOP) is a rare human condition characterized by abnormal bone formation triggered by the R206H mutation in the ACVR1 receptor which leads to excessive BMP signaling. Intriguingly, the manifestation of FOP occurs postnatally despite embryonic activity of the receptor and the goal of this project is to uncover why embryos seem unaffected by the condition.
Project Aims:
- Aim 1: By investigating cellular and molecular changes in FOP mutant limb buds from the earliest stages, we aim to identify the compensatory mechanisms that protect the embryo from disease manifestation.
- Aim 2: The effects of excessive BMP signaling on FOP disease progression in the absence of BMP antagonism will be investigated genetically. Cellular, molecular, and phenotypic alterations will be analysed in embryos. Elucidating the mechanisms that enable embryos to evade or delay the onset of disease symptoms will be relevant for identifying potential therapeutic strategies for FOP.
This project encourages student interaction with several group members.
Methodologies:
Over approximately 9 months, the research project will immerse the student in a diverse array of molecular and cellular techniques. These include mouse genetics to investigate gene interplay affecting disease onset, phenotypic studies on cartilage and bone formation and the isolation and 3D culturing of limb mesenchymal progenitors from both wild type and FOP model for comparative analysis of molecular and cellular differentiation. Advanced techniques such as fluorescent RNA in situ hybridization (HCR) and immunofluorescence will enable detailed cellular studies.
This project provides the student with a valuable combination of scientific methodology, analytical thinking, and innovative research skills. Participation in research seminars, journal clubs, and the master thesis writing process will strengthen their ability to effectively communicate scientific findings in English, offering an enriching educational and research experience.
This project can be started as agreed with the master student.
Interested? Then drop us an email with your CV to arrange for an interview and project discussion.
We look forward to hearing from you
#J-18808-Ljbffr-
Phd Position
vor 2 Wochen
Basel, Schweiz Universität Basel VollzeitThe Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 800 employees, the...
-
Basel, Schweiz Bio Engineering Laboratory & Novartis VollzeitJob description In this project, we aim at exploring how in vitro models can be leveraged to improve preclinical drug selection, in particular for gene therapy development. Building on the group expertise in blood-brain-barrier platforms, the postdoc will develop new in vitro models of the human and mouse blood-brain-barrier and benchmark the in vitro...
-
Basel, Basel-Stadt, Schweiz talendo AG VollzeitAbout the RoleAt Roche, we are committed to harnessing the power of data science to drive breakthroughs in healthcare. As a Postdoctoral Scientist in Predictive Analytics, you will play a critical role in our mission to advance the understanding of neurodegenerative diseases.This project aims to develop advanced statistical and...
-
Disease Modelling Scientist
vor 2 Wochen
Basel, Schweiz CTC Resourcing Solutions Vollzeit**Disease Modelling Scientist - 5204 URA** Our client is a pioneer in Drug Discovery and Development and one of the frontrunners in Personalised Healthcare. As the world's largest R&D spender in the pharmaceutical and diagnostics domain, they work in a vast number of drug discovery & therapeutic areas and are highly recognized internationally. This role is...
-
Disease Modeling Lead
vor 2 Wochen
Basel, Schweiz Coopers Group AG Vollzeit**Disease Modeling Lead** For our pharmaceutical client in Basel we are looking for a person who will focus on leading the modeling strategy to support the development of a modeling platform for oncology biomarker research in the area of cancer immunotherapy. **Tasks & Responsibilities**: - Implement parameter inference techniques using the existing model...
-
Infectious Disease Modeler
Vor 2 Tagen
Basel, Schweiz Swiss TPH VollzeitThe Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...
-
Infectious Disease Modeler
Vor 2 Tagen
Basel, Schweiz Universität Basel VollzeitThe Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...
-
Infectious Disease Modeler
vor 2 Wochen
Basel, Schweiz Universität Basel VollzeitThe Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...
-
Infectious Disease Modeler
Vor 5 Tagen
Basel, Schweiz Universität Basel VollzeitThe Swiss Tropical and Public Health Institute (Swiss TPH) is a world-leading institute in global health with a particular focus on low - and middle-income countries. Associated with the University of Basel, Swiss TPH combines research, education and services at local, national and international levels. 900 people from 80 nations work at Swiss TPH focusing...
-
Basel, Schweiz F. Hoffmann-La Roche AG VollzeitResearch Associate in vivo models in Cardiovascular and Metabolic DiseasesThe PositionA healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.In Roche’s...
-
Basel, Schweiz F. Hoffmann-La Roche AG VollzeitResearch Associate in vivo models in Cardiovascular and Metabolic Diseases The Position A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. In Roche’s...
-
Disease Modeling Scientist
vor 2 Wochen
Basel, Schweiz Global Kader Personal Vollzeit**INTRODUCTION**: As a preferred supplier for Roche Basel we are looking for an individual as **Disease Modeling Scientist (M/F/d)**: - (contract for 1 year, with possible extension). The earliest start date is within two months, latest start date is 1st May. Remote/Home Office: possible on discussion. **ASSIGNMENT DESCRIPTION**: - Implement parameter...
-
Disease Modelling Scientist
vor 2 Wochen
Basel, Schweiz Hobson Prior VollzeitHobson Prior are seeking for a Disease Modelling Scientist to join a fantastic pharmaceutical corporation on a contract basis. Our client is focused on providing life-changing remedies for those who suffer from serious illnesses. Please note that to be considered for this role you must have the right to work in this location. **Key Responsibilities**: -...
-
Basel, Basel-Stadt, Schweiz Roche VollzeitAs a Research Associate in the Cardiovascular and Metabolic Diseases department, you will be part of a dynamic team focused on transforming science into medicines. Our mission is to make transformative medicines for patients to tackle some of the world's toughest unmet healthcare needs.We believe that our success is built on innovation, curiosity, and...
-
Basel, Schweiz Roche VollzeitRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...
-
Research Associate In-vivo Pharmacology
vor 3 Wochen
Basel, Schweiz Work Selection Vollzeit**Beschreibung**: For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **Research Associate in-vivo Pharmacology** for a temporary contract of 12 months with a possible extension. **Tasks**: - Help to refine and independently execute a mouse models used for in vivo studies related to lung...
-
Basel, Schweiz Ridgeline Discovery GmbH Vollzeit**Ridgeline Discovery is looking for** a SVP, Pharmacology and Translational Disease Models**.** **Ridgeline Discovery **is currently supporting Six Peaks Bio, a newly founded biotech start-up in finding a SVP, Pharmacology and Translational Disease Models. **RESPONSIBILITIES** - In vitro/molecular pharmacology activities - Complex in vitro cell based and...
-
Basel, Schweiz F. Hoffmann-La Roche Gruppe VollzeitRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...
-
Basel, Schweiz F. Hoffmann-La Roche Gruppe VollzeitRoche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people’s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche,...
-
Basel, Schweiz TN Switzerland VollzeitPostdoc Position in the Development of In Vitro Models of the BBBClient:Bio Engineering Laboratory & NovartisLocation:BaselJob Category:OtherJob Reference:8cd109bf96c0Job Views:9Posted:21.01.2025Expiry Date:07.03.2025Job Description:In this project, we aim at exploring how in vitro models can be leveraged to improve preclinical drug selection, particularly...