Director of Quantitative Systems Pharmacology

Changehow drugs are developed today for new treatments tomorrow

We are a team of highly motivated individuals who wantto impact how drugs are developed today. If you have great computational skills and dare to use them for tackling the complex biology underlying human disease:LYO-X is the right place for you.

At LYO-X, you can maximize your individual potential and expertise while pursuing a career that reflects your passions and lifestyle.

Director of Quantitative Systems Pharmacology (QSP) Modeling

We are currently seeking a talented and innovative Director of Quantitative Systems Pharmacology (QSP) Modelingto provide scientific and project leadership in the areas of quantitative systems pharmacology and mechanistic PK/PD modeling projects of different therapeutic modalities.
The ideal candidate will manage junior modelers, lead multiple concurrent client projects working closely with client teams to build fit-for-purpose mathematical models that help drive decisions in drug development.

LYO-X is an established Swiss company located in Basel providing consulting and Quantitative Systems Pharmacology modelling services for the preclinical and clinical development of drugs to our customers worldwide. Our customers range from highly innovative biotechnology companies, international large pharmaceutical companies to non-profit health organizations.
LYO-X is one of the very few companies globally that is successfully applying Quantitative Systems Pharmacology as a service to help develop the next generation of drugs to bring better medicines to patients faster.

At LYO-X we want our associates to grow and develop both inside and outside of work and we offer a flexible and collaborative working environment, to enable this.
LYO-X provides the space to maximize your potential and the opportunity to grow your expertise through exiting and novel project work, interaction with global clients and learning from other experienced colleagues around you.

Required Skills, Abilities and Education:

• PhD or equivalent in biomedical engineering, chemical engineering, biophysics, mathematics, biology, biochemistry, pharmaceutical sciences or related field
• At least 10 years of pharmaceutical or biotech experience in building QSP or mechanistic PK/PD models
• Excellent understanding of methodologies and principles of advanced mathematical modeling and simulations
• Understanding of pharmacokinetics and pharmacodynamics modeling for preclinical and clinical bio-therapeutics
• Understanding of drug discovery and development processes
• Expert in differential equations and coding with MATLAB, R and other relevant scientific computing languages
• Experience with population PK/PD models, statistical modeling is required
• Excellent oral and written communication skills; ability to engage and effectively communicate within a cross-disciplinary team is highly valued
• Prior experience as a project team representative on a multifunctional team is required.
• Experience managing workload and timeline and track record of delivering work on time
• Record of scientific achievement through peer-reviewed publications, invited oral presentations, or patents
• Passion for data driven analysis, applying innovative quantitative solutions to advance projects.

If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, academic transcripts and job references. Please send your application to hiring@lyo-x.com.

Quantitative Systems Pharmacology Modeler

Are you a highly motivated data scientist and mathematical modeler with a Masters or PhD degree who wants to impact drug development today
If you have great computational skills and are excited to use them to tackle complex biology underlying diseases; then LYO-X is the right place for you

LYO-X is an established Swiss company located in Basel providing consulting and Quantitative Systems Pharmacology modelling services for the preclinical and clinical development of drugs to our customers worldwide. Our customers range from highly innovative biotechnology companies, international large pharmaceutical companies to non-profit health organizations.
LYO-X is one of the very few companies globally that is successfully applying Quantitative Systems Pharmacology as a service to help develop the next generation of drugs to bring better medicines to patients faster

At LYO-X we want our associates to grow and develop both inside and outside of work and we offer a flexible and collaborative working environment, to enable this.
LYO-X provides the space to maximize your potential and the opportunity to grow your expertise through exiting and novel project work, interaction with global clients and learning from other experienced colleagues around you.

We are looking for individuals with excellent analytical and conceptual skills and a background in engineering, biophysics, computational sciences or other related fields. Experience in life science, pharmacology or drug development is preferable but not required. The desired candidate should have graduated with a recent Master’s or PhD degree from the ETHZ, EPFL or other high ranking university.

Professional requirements, required skills & competencies:

• Master’s or PhD degree from the ETHZ, EPFL or other recognized university.
• Rigorous, excellent analytical skills
• Pro-active, self-sufficient and can work independently
• Can communicate about scientific topics proficiently
• Proficient in oral and written English
• Expert in scientific programming using Matlab and R
• Confident in understanding, using and solving ordinary differential equations (ODE)
• Other versatile computational skills are desired in fields such as image processing, partial differential equations (PDE), machine learning, statistical learning or parallel computing
• Strong team player, good communication skills and ability to work with cross-cultural and diverse project teams and clients

If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, academic transcripts and job references. Please send your application to hiring@lyo-x.com.

Software for animal-to-human scaling of biotherapeutics

Project:

Animal-to-human scaling of novel biotherapeutics is an important step in drug development. We want to develop a software that integrates existing data on preclinical and clinical pharmacokinetics of different biotherapeutic formats with mathematical models. The software should be able to visualize pharmacokinetic profiles across different species and provide model predictions in animal and in human.

Internship Goals:

• Review literature on monoclonal antibody kinetics in preclinical species and in human.
• Digitize literature data and build a pharmacokinetics data base.
• Develop mathematical models.
• Develop an interface to query data and mathematical models for the prediction in humans.

Requirements:

• Rigorous, excellent analytical skills, pro-active.
• Good at communication of scientific topics.
• Proficient in oral and written English.
• Good mathematical and statistical skills.
• Expert in scientific programming using R and Shiny.

Languages:

Location:

Basel.

Company:

LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.

Contact:

If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, Bachelors and Masters grades, reference letters and job references. Please send your application to hiring@lyo-x.com.

Simulation software for antibiotics effect prediction

Project:

Antibiotics resistance is a huge issue that is also getting more public awareness due to its criticality. An important part of addressing this problem is the correct usage of antibiotics. For this one has to know if an antibiotic is effective against a certain bacterial strain and how it should be dosed. We are implementing a software platform that allows users to predict the probability of successful treatment based on the bacterial strain and the type of drug and the dose and regimen. This software should be accessible via a web interface that is programmed in R and Shiny.

Internship Goals:

• Implement a mathematical model of antibiotics pharmacokinetics.
• Implement a mathematical model of antibiotics effect.
• Develop an interface in shiny for the mathematical models.
• Rigorous testing of the interface for usability.

Requirements:

• Rigorous, excellent analytical skills, pro-active.
• Good at communication of scientific topics.
• Proficient in oral and written English.
• Good mathematical and statistical skills.
• Expert in scientific programming using R and Shiny.

Languages:

Location:

Basel.

Company:

LYO-X is a Swiss company located in Basel providing global consulting and Systems Pharmacology modelling services dedicated to the preclinical and clinical development of biologics and cell-based therapies.

Contact:

If you are interested and would like to contribute to the growth of LYO-X, we would be pleased to receive your application including a letter of application, curriculum vitae, Bachelors and Masters grades, reference letters and job references. Please send your application to hiring@lyo-x.com.