Role of Ros in The Pathophysiology of Osteoarthritis

vor 2 Wochen

Genf, Genf, Schweiz Faculté de Médecine - Université de Genève - Suisse Vollzeit

Role of ROS in the pathophysiology of osteoarthritis:

  • Réf
-
ABG-114814

  • Sujet de Thèse 28/05/2023
  • Autre financement public
  • Faculté de Médecine
  • Université de Genève
  • Suisse
  • Lieu de travail
  • Geneve
  • Suisse
  • Intitulé du sujet
  • Role of ROS in the pathophysiology of osteoarthritis
  • Champs scientifiques
  • Biologie
  • Santé, médecine humaine, vétérinaire


 Mots clés
  • ROS, NADPH oxidase, cartilage, osteoarthritis, mice
    Description du sujet:

PhD position in osteoarthritis research
Applications accepted between: 01 Nov Oct 2027

Organization:
Department of Orthopedic Surgery, University Hospital & Faculty of Medicine

Location:
University Medical Center, Geneva, Switzerland

Job description:

The Cell Therapy & Musculoskeletal Disorders Laboratory, Department of Orthopedic Surgery,

Geneva University Hospital has a position available for a highly motivated PhD student to

study the role of ROS in the pathophysiology of osteoarthritis.

The PhD student will investigate the role of NADPH oxidase 4 (NOX4) in the pathophysiology

chondrocyte proliferation, cell cycle analysis, inflammation, chondrocyte differentiation,

chondrocyte metabolism, culture of cartilage explants, generation and breeding of

genetically-modified mice, and induction of osteoarthritis in mice followed by histological and

morphological evaluation by micro-CT.

Qualifications:
Master of science degree is mandatory.

Preference will be given to those individuals who have demonstrated experience in

molecular biology, flow cytometry, advanced microscopy, histological techniques including

immunohistochemistry, immunofluorescence, western blot, micro-CT image reconstruction

and analysis.

technical and competitive challenges, as well as to participate effectively in team efforts.

Contract:
PhD position for four years, expected to start, if possible, November 1st 2023. Pay

is according to the rules of the Swiss National Science Foundation. Student will be enrolled in

the PhD School of Life Sciences at the Faculties of Medicine at the University of Geneva.

  • Your Curriculum Vitae.
  • The names and addresses of 2 referees.
  • A letter of reference.

Prise de fonction:

  • 01/11/2023
    Nature du financement:
  • Autre financement public

Précisions sur le financement:

Présentation établissement et labo d'accueil:

  • Faculté de Médecine
  • Université de Genève
  • Suisse

Location:
Faculté de médecine de l'Université de genève


Our research group is involved in basic and translational research in the field of osteoarthritis (OA), led by Pr Didier Hannouche, and in the field of skeletal muscle stem cells (MuSC), led by Dr Thomas Laumonier.


In OA, articular cartilage follows a progressive degeneration, where low-grade inflammation could play a pivotal role through an oxidative stress-dependent mechanism and exposure to reactive oxygen species (ROS).

We hypothesize that ROS production by chondrocytes through NADPH isoform 4 (NOX4), plays a noxious role in OA pathogenesis.

For this purpose, we investigate the implication of NOX4 in the pathophysiology of OA, both in vivo and in vitro.

The laboratory has also a long experience in the isolation, culture, characterization, and transplantation of human MuSC.

The research work focuses mainly on the development of cell therapy strategies in the treatment of skeletal muscle disorders, including myopathies.

We demonstrated that human muscle reserve cells (MuRC), generated in vitro, are like quiescent MuSC with properties required for their use in cell therapy.

The objective of the ongoing studies is to characterize the molecular signature, the metabolic profile of human MuRC and to identify new mechanisms that regulate the function of these cells in vitro and in vivo.


Site web:

Intitulé du doctorat:

  • PhD
    Pays d'obtention du doctorat:
  • Suisse

Etablissement délivrant le doctorat:

  • UNIGE
    Ecole doctorale:
  • Life Sciences, Geneva University
    Qualifications:
Master of science degree is mandatory.

Preference will be given to those individuals who have demonstrated experience in

molecular biology, flow cytometry, advanced microscopy, histological techniques including

immunohistochemistry, immunofluorescence, western blot, micro-CT image reconstruction

and analysis.

technical and competitive challenges, as well as to participate effectively in team efforts.- 31/08/2023

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