Technical Screening Scientist

Vor 7 Tagen


Schlieren, Zürich, Schweiz CDR-Life AG Vollzeit
Identify new antibody fragments to generate first in-class immune-oncology drugs_


You will play an important role in the screening and hit identification of antibodies and antibody-derived molecules while collaborating with colleagues to deliver first-in-class biologics.

In addition, you will help to drive innovative approaches for drug discovery using novel antibody and protein engineering technologies.

We are looking for a highly motivated and collaborative team member with a passion for drug discovery research, who enjoys working in a fast-paced and highly dynamic working environment.


Responsibilities

  • Execute and support antibody screening campaigns
  • Perform phage display antibody library generation and selection
  • Plan and execute molecular cloning activities
  • Oversee ELISAbased binding characterization assays
  • Perform FACSbased Bcell sorting and contribute to the development of the screening platform
  • Cultivation and characterization of isolated Bcells
  • Ensure best practices of research, data management and archiving
  • Proactively prepare and/or organize required equipment, consumables and reagents

Your Profile

  • Apprenticeship, B.Sc. or MSc. in biology, biochemistry, immunology, or a related discipline
  • Demonstrated expertise in antibody display techniques (e.g. phage, yeast or mammalian)
  • Expertise in molecular biology and cell culture techniques
  • Experience with ELISA assays for antibody characterization
  • Laboratory experience in flow cytometry or FACSbased cell sorting is a plus
  • Experience with antibody affinity maturation and antibody humanization would be a plus
  • Experience in recombinant protein production using mammalian cells would be a plus
  • Ability to work independently and wellorganized in a team environment
  • Positive and proactive mindset


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