Technical Expert "On-chip Organoid Patterning"

vor 4 Wochen

Basel, Schweiz ETH Zürich Vollzeit
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We are looking for a highly motivated and collaborative individual to join the Quantitative Developmental Biology group as a Technical Expert (3 year position) in the Department of Biosystems Science and Engineering (D-BSSE) of the ETH Zürich, located in Basel, Switzerland. The candidate will work as part of a multidisciplinary team and be passionate about science, technology, collaboration and communication.Job description

The goal of this position is to develop a novel microfluidic chip for on-chip neural organoid culture to allow for the spatially and temporally controlled supply of patterning factors to the growing organoid. Activities will include the design and fabrication of microfluidic chips, the generation of human neural organoid cultures, adjustments of culture protocols, and the molecular phenotyping of the on-chip generated model systems of different regions of the human brain. The position is embedded in the Quantitative Developmental Biology group, which uses stem cell-derived three-dimensional organoids, single-cell genomics, CRISPR genome engineering, microscopy and advanced computational approaches to explore human development and disease.Profile

The candidate must have a PhD degree in Bioengineering or a related field with several years of work experience. The candidate must bring very good social skills (teamplayer) as well as fantastic communication skills and fluency in oral and written English.

The successful candidate will have experience across the following areas:

  • Human and mouse ESC and iPSC derived neural organoid culture (neural tube, spinal cord, and brain)
  • Microengineering with strong clean room experience; photo/soft lithography, DRIE etching, mask aligner, photoresist laser writer, mask processing, plasma etching, scanning electron microscopy
  • Microfluidic device development with focus on organ-on-a-chip (especially developing hydrogel-incorporated microfluidic devices and laser-etching experience)
  • 3D modelling and simulation (experience with AutoCAD, Blender, and COMSOL)
  • Imaging (confocal microscopy, live cell imaging, time-lapse microscopy, light sheet microscopy) as well as with tissue sectioning (cyrosection, Vibratome), immunofluorescence and fluorescence in situ hybridisation
  • Single-cell genomics experimentsWe offer
    • Highly competitive conditions in a dynamic and international research community in Basel
    • ETH Zürich is an equal-opportunity employer with family-friendly work policiesWorking, teaching and research at ETH ZurichWe value diversityIn line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.Curious? So are we.

      We look forward to receiving your online application with the following documents:

      • Curriculum vitae
      • Academic transcripts
      • Contact details for at least two academic references

        Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

        Further information about D-BSSE can be found on our website. Questions regarding the position should be directed to Prof. Dr. Barbara Treutlein via email at Write an email (no applications).

        For recruitment services the GTC of ETH Zurich apply.About ETH ZürichETH Zurich is one of the worldâs leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.

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