The Use of The Nose-to-brain Administration Pathway in Autoimmune Diseases of The Central Nervous System

vor 1 Woche

Bern, Schweiz Université de Berne Vollzeit

**The use of the nose-to-brain administration pathway in autoimmune diseases of the central nervous system**:

- Réf **ABG-132115**
- Sujet de Thèse
- 21/05/2025
- Financement public/privé
- Université de Berne
- Lieu de travail- Berne - Suisse
- Intitulé du sujet- The use of the nose-to-brain administration pathway in autoimmune diseases of the central nervous system
- Champs scientifiques- Biologie
- Psychologie, neurosciences
- Mots clés- AQP4, neuromyelitis optica spectrum disorders, animal models, neuroscience, astrocytopathy, biomarkers,

**Description du sujet**:
The recruited PhD student will carry out experiments in disease models, and will perform molecular and histological analyses to characterize the changes in the CNS. Some experiments will be realized in the visual system which represents an accessible part of the CNS (Joly et al 2022 Journal of Neuroinflammation; Mdzomba et al 2020 Cell Death Dis). The experimental work will be conduceted under the supervision of Prof. Pernet, at the department of Neurology of Bern University Hospital-Inselspital. The selected PhD student will be registered in the PhD program of the Graduate School for Cellular and Biomedical Sciences (GCB) at the University of Bern. Presentations in local and international scientific conferences will be part of the doctoral training.

**Nature du financement**:

- Financement public/privé

**Précisions sur le financement**:

- Grant from Swiss National Science Foundation

**Présentation établissement et labo d'accueil**:

- Université de Berne

Our lab is part of the Center for experimental neurology (ZEN), located at the department of Neurology of Bern University Hospital-Inselspital, in Switzerland.

Our lab is focused on experimental approaches allowing the delivery of neurotherapeutics in the central nervous system (CNS) to promote neuronal repair and neurological recovery in autoimmune and neurodegenerative diseases. Indeed, the blood-brain barrier is a major obstacle to the passage of therapeutics from the blood flow to the brain. However, we have recently shown that the intranasal pathway could be used to neutralize CNS proteins preventing neuronal repair and functional recovery (Pernet et al 2023 Cell Death Discov). Our new studies aim at elucidating the basic mechanisms underlying antibody transport from the nose to the brain/spinal cord and at testing innovative treatments that may limit inflammatory processes in the CNS. The proposed PhD project includes the elucidation of neuroinflammatory processes in autoimmune diseases of the CNS.

**Intitulé du doctorat**:

- PhD in Neurosciences

**Pays d'obtention du doctorat**:

- Suisse

**Etablissement délivrant le doctorat**:

- University of Bern

**Ecole doctorale**:

- Graduate School for Cellular and Biomedical Sciences (GCB)- 13/06/2025

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