Medicinal Drug Design Lead

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

**About Iso**:
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

**Medicinal Drug Design Lead, London or Lausanne**:
**About the Medicinal Drug Design Team**:
We are a growing team of medicinal chemists who sit within the Drug Design and Medical Research function at Isomorphic Labs. Our primary focus is to lead the chemistry on our internal portfolio and collaboration projects, but we also use our domain knowledge to work collaboratively with our AI/ML colleagues to build the Platform and drive forward success and innovation in drug design. We work closely together in a supportive environment, where everyone is valued for the expertise and experience they bring to the group. We have a strong growth mindset and ensure we prioritise continued development and learning as medicinal chemists.

**Your impact**:
As part of the ongoing expansion of our Drug Design and Medical Research function, we are looking to recruit a number of Medicinal Chemistry positions in our Medicinal Drug Design Team.

Ready to elevate your scientific career? Isomorphic Labs offers ambitious scientists a unique environment to tackle stimulating challenges, pushing your boundaries and accelerating your personal and professional growth.

Please note that this is a scientific leadership role, where we will need you to take an active hands-on role as an individual contributor rather than being a people manager.

**What you will do**:

- Collaborate both internally and with third party organisations, interacting within multidisciplinary teams, to support data-driven delivery of high quality scientific solutions to complex technical problems.
- Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs).
- Manage CRO resource and other members of the growing team, mentoring and supporting their development.
- Prepare detailed scientific proposals and reports to support new and ongoing programs.
- Embrace and champion our culture of inclusion and continuous professional development.

**Skills and qualifications**:
**Essential**:

- PhD in Chemistry or a related technical field, or equivalent experience.
- Good foundation in medicinal chemistry with a minimum of 5+ years previous industrial experience operating as an individual contributor within a pharma/biotech/CRO setting.
- Experience in a lead chemist role.
- Experience and expertise working on Lead Optimisation programs, with familiarity of optimisation of Drug Metabolism and Pharmacokinetics (DMPK).
- Experience of working with and closely managing CRO resource.
- Track record of authorship of relevant scientific manuscripts and inventorship of composition of matter patents.

**Nice to have**:

- Direct experience of working in a Pharma, Biotech or CRO on drug discovery collaborations, ideally in a chemistry or project lead role.
- Experience of contributing to Structure-Based Drug Design problems.

**Culture and values**:
We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

**Thoughtful**
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

**Brave**
Brave