Rna Biologist/bioinformatician

vor 2 Wochen

Basel, Schweiz Coopers Group AG Vollzeit

**RNA Biologist/Bioinformatician**

The focus of the position is to build and develop novel therapeutic approaches in the gene therapy space by using high-throughput and next generation sequencing (NGS) methods.

**Responsibilities**:

- You bring deep scientific RNA and computational biology expertise as a key member of project teams.
- You develop in silico and/or wet lab technologies to design, screen and analyze genetically encoded transgenes with various modes of actions, such as splice modification, RNA knockdown, RNA and DNA editing, and tunable transgene expression.
- You facilitate our understanding of RNA (sequence and structure-based) as a target and as a therapeutic modality (shRNA, gRNA, ribozymes, etc) for viral and non-viral gene therapies.
- You generate ideas for innovative ways to modulate gene expression, as well as ideas for testing novel therapeutic mechanisms.
- You develop nurturing trustful relationships and effective collaboration with internal and external partners
- You have strong oral and written communication skills, and are proficient in working with cross-functional and multidisciplinary teams

**Requirements**:

- PhD in molecular biology, genetics/genomics, computational biology, or related fields.
- Deep expertise in RNA biology and/or synthetic biology, ideally in the field of gene therapy and RNA therapeutics.
- trong experience with the in silico design of genetic elements and expression cassettes, coupled to bioinformatics analysis of high-throughput screening and NGS datasets.
- A proven scientific-track record through impactful publications in relevant fields, patents, or substantial contributions to drug development programs
- Proficiency in using Python and R/Bioconductor
- Experience in bash scripting and working in Linux and HPC environment
- Proficiency in data analysis and machine learning techniques (clustering, generalized linear models, data visualization, data mining and reporting, generative AI)

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