Chemical Research Scientist

vor 1 Woche


Basel, Basel-Stadt, Schweiz talendo AG Vollzeit
About the Role

We are seeking a highly skilled Chemical Research Scientist to join our team at Roche Innovation Center Basel, Switzerland. As a key member of our DNA-encoded library technology (DELT) team, you will be responsible for developing novel chemistry-based approaches to advance our drug discovery efforts.

In this temporary 12-month position, you will work closely with our multidisciplinary team to design, synthesize, and optimize DNA-encoded libraries using state-of-the-art techniques such as automation and combinatorial methodology. You will also collaborate with colleagues and academic groups to translate traditional reactions into DNA-compatible variants.

Responsibilities
  • Plan and contribute to the discovery and development of novel DNA-compatible chemistry for use in DNA-encoded library synthesis
  • Utilise automation and combinatorial methodology for the synthesis of DNA-encoded libraries
  • Purify and characterise oligonucleotide-small molecule conjugates using techniques such as HPLC and mass spectrometry
  • Optimise novel and current reaction protocols for application in DELT


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