Head of Process Chemistry and Catalysis

vor 1 Monat

Basel, Basel-Stadt, Schweiz Roche Vollzeit
Job Title: Section Head of Process Chemistry

Roche is seeking a highly experienced and skilled Section Head of Process Chemistry to lead our Process Chemistry & Catalysis department. As a key member of our Synthetic Molecules Technical Development team, you will be responsible for driving the development of safe, robust, and sustainable commercial manufacturing processes for synthetic drug substances.

Key Responsibilities:
  • Lead a team of scientists and associates in the design of new synthetic routes and the development of commercial manufacturing processes.
  • Support and deliver a portfolio of projects with a focus on oligonucleotides and peptides by assigning resources, setting priorities, and providing sound judgment for decision making and problem solving.
  • Foster the development of cost-efficient and robust processes and process understanding by using state-of-the-art science and methodologies to enable lean manufacturing.
  • Provide scientific and technical input to project teams and further develop your section towards a lean and agile organization.
  • Support Roche's regulatory submissions by applying principles of Quality by Design to drug substance development and corresponding documentation while ensuring compliance with quality and regulatory requirements.
  • Actively support the departmental digitalization and M&S efforts as well as contribute to defining the department's future technical and regulatory strategies and concepts.
Requirements:
  • A PhD degree in organic chemistry with at least 10 years' experience in process chemistry for synthetic molecules, spanning the entire range from route design, process development, process characterization, and process transfer to commercial manufacturing.
  • Excellent people leadership skills and a strong ability to act visionary and be the catalyst, mentor, and architect for teams and members.
  • Excellent knowledge in oligonucleotide and peptide chemistry and extensive experience in working with external collaboration partners in Europe, US, and Asia.
  • Comprehensive understanding of sustainable process development and how to implement green chemistry concepts into manufacturing processes and excellent understanding of scientific methodology, principles of data integrity, and good documentation practices.
  • Excellent communication skills and a strong ability of building and maintaining constructive and effective relationships with stakeholders as well as strong collaboration and team building skills.
About Roche:

Roche is a leading global healthcare company with a strong commitment to innovation and excellence. Our Synthetic Molecules Technical Development department is responsible for the technical development of our synthetic molecules pipeline and manufacture of drug substance and drug product for clinical studies across our synthetic molecules manufacturing network.

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