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Therapeutic Development Lead
vor 1 Woche
About the Position
The University of Basel, a renowned institution among the world's top universities, seeks an experienced and innovative Senior Scientist to lead the development and characterization of T cell-based therapies for EBV-associated cancer. The ideal candidate will bring expertise in immunology, multicolor flow cytometry, immune assays, genome-editing technologies such as CRISPR/Cas9, library design, and in vivo experimental design and execution.
Key Responsibilities
- Design, optimize, and implement strategies for developing T cell-based therapeutic products;
- Lead preclinical studies to evaluate T cell function, persistence, and efficacy;
- Develop and execute multicolor flow cytometry panels to assess immune cell phenotypes and functions;
- Design and perform immune assays, including cytokine profiling, cytotoxicity assays, and proliferation assays;
- Utilize genome-editing tools to engineer transgenic TCR libraries for enhanced therapeutic potential;
- Analyze experimental omics data;
- Contribute to the preparation of regulatory documents and grant applications;
- Support technology transfer processes for manufacturing T cell therapy products;
- Work collaboratively with multidisciplinary teams, including bioinformatics, regulatory, and clinical operations groups;
- Mentor junior scientists and research associates;
- Analyze complex datasets to inform decision-making and improve product development strategies;
- Prepare high-quality scientific presentations, reports, and publications to communicate findings internally and externally.
Requirements
We are seeking an individual with a PhD in Immunology, Cellular Biology, or a related field, preferably with postdoctoral experience. A proven track record in T cell therapy research and development is essential, along with extensive hands-on experience in immune cell assays and multicolor flow cytometry. Proficiency in CRISPR/Cas9 and library design, genomics and/or transcriptomics data analysis, and experience with clinical translation of cell-based therapies are highly desirable.
