Molecular Biology Researcher

vor 4 Wochen


Zürich, Zürich, Schweiz Institute of Molecular Biology & Biophysics, ETH Zurich Vollzeit

Job Opportunity

We are seeking a highly motivated researcher to investigate the regulation of the microtubule cytoskeleton by protein complexes such as the gamma-TuRC. The successful candidate will have the opportunity to utilize state-of-the-art light and electron microscopy instrumentation, including a Nikon N-STORM equipped for TIRF microscopy and multiple Titan Krios EM scopes, hosted and maintained at ETH Zurich's imaging facility, ScopeM.

The project will involve using structural biology methods such as cryo-electron microscopy and X-ray crystallography, as well as single molecule light microscopy such as Total Internal Reflection Fluorescence (TIRF), to visualize components of the gamma-TuRC as the complex nucleates microtubules.

Requirements

  • Research interest in cell biology, structural biology, biochemistry, and/or biophysics
  • Curiosity about the inner workings of the cell and a passion for basic science
  • Experience with basic molecular biology, cell culturing, and/or protein purification methods
  • Experience with cryo-EM sample preparation and structure determination using various modern software tools (e.g. cryoSPARC and RELION)
  • An MSc degree in biochemistry, cell biology, structural biology, biophysics, or disciplines related to the PhD position
  • Good knowledge of English for writing scientific papers and active participation in internal meetings and international conferences

Working Conditions

The successful candidate will be part of a dynamic and collaborative research group at the Institute of Molecular Biology & Biophysics, ETH Zurich.



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