Senior Scientist in Protein Degradation Chemistry

Vor 5 Tagen


Basel, Basel-Stadt, Schweiz Matterhorn Biosciences AG Vollzeit
Oncology Focused Research

Zenith Therapeutics is a leading player in redefining drug discovery through innovative approaches to protein degradation. With a primary focus on oncology and immune modulation, our team has successfully identified key ligases that facilitate the turnover of challenging transcription factors, enabling the creation of novel druggable targets.

We are looking for a highly skilled Senior Scientist in computational chemistry to join our research team. In this role, you will be responsible for developing and implementing cutting-edge computational strategies to identify and optimize molecular glue compounds. Your extensive expertise in cheminformatics and structure-based drug design will drive program success from early stages to late-stage optimization.

Key Responsibilities:

  • Design and execute computational chemistry experiments in collaboration with cross-functional teams.
  • Develop and deploy novel algorithms for predicting protein-ligand interactions and optimizing molecular structures.
  • Analyze complex datasets to inform critical go/no-go decisions throughout the drug discovery process.
  • Collaborate with colleagues to develop strategic recommendations for therapeutic area prioritization.

Essential Qualifications:

  • Ph.D. in computational chemistry or a related field with a strong publication record.
  • 5+ years of industrial experience in the pharmaceutical or biotechnology sector, with expertise in computational chemistry.
  • Demonstrated expertise in cheminformatics, structure-based drug design, and data analysis tools.
  • Excellent written and verbal communication skills, with experience collaborating with international teams.
  • Able to thrive in a dynamic, fast-paced environment with continuous learning and professional growth opportunities.


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