Postdoctoral Fellow in Local Brain Cancer
vor 12 Stunden
_Laboratory Animal Science_
**Postdoctoral fellow in local brain cancer immunotherapy**
**80-100 %**:The vom Berg lab seeks to hire a motivated postdoctoral researcher with a passion for cancer immunotherapy and neuroimmunology. Our main research goal is to elucidate the mechanisms of exclusively local immunotherapy of brain cancer with potent immunomodulators. Brain compartment locked cytokines show higher treatment efficacy at mínimal systemic footprint in murine GBM and would allow to harness their full therapeutic potential without constraints of systemic toxicity.
The concept is applicable to antibodies and allows localized therapy with immune checkpoint blockade. Such a therapeutic approach might leverage distinct immunological mechanisms compared to systemic treatment. The project involves transcriptome and cytokine profiling, flow cytometry in murine disease models as well as in patient-derived perfused explant cultures and is embedded in an ongoing collaboration with the group of Prof. Gregor Hutter in Basel.
**Your responsibilities**:
Perform cutting-edge research within a young international team. Frame questions and test them experimentally. Drive the project independently.
**Your profile**:
We are specifically looking for an experimental profile holding a PhD in neuroscience, biology or immunology with a strong background, based on a solid publication record, in tumor immunology in vivo models, transgenic mouse models, flow cytometry and histology and molecular techniques (PCR, Western Blotting, ELISA, RNAseq). The successful applicant should be excited about science, creative, thorough and well organized. Excellent English communication skills including writing skills for scientific publications are mandatory.
**What we offer**:
We offer an international, English-speaking work environment. The University of Zürich provides a vibrant scientific environment, state-of-the art equipment on site and the opportunity to learn cutting-edge technologies. In particular, the lab is embedded in the Institute of Laboratory Animal Science which offers a wide range of courses on experimental techniques. The position is initially for 2 years with a competitive Swiss salary and the possibility for extension and participation in the translational development of this approach. The position is available immediately and will be open until filled. The employment start date is to be mutually agreed
**Place of work**:
Schlieren, Switzerland
**Start of employment**:
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