Discovery Postdoc in Oncology Radioligand Therapies

vor 2 Wochen

Basel, Schweiz Novartis Vollzeit

394253BR

**Discovery Postdoc in Oncology Radioligand Therapies**:
Switzerland

**About the role**

There is a unique opportunity for a Discovery Postdoctoral Fellow to explore the underlying biology of novel Radioligand Therapies (RLTs), including the effect of RLTs on the tumor and its stromal microenvironment.
The Discovery Fellow will have the opportunity to conduct innovative, interdisciplinary research and publish their results in leading journals. You will be part of our Oncology, Pharmacology team in Basel, Switzerland working very closely with Oncology Data Sciences.
RLT is a form of precision nuclear medicine which specifically directs radiation to target cells in the tumor. This cutting-edge technology has demonstrated remarkable promise for cancer patients, with two Novartis compounds
- Pluvicto (177Lu-PSMA-617) and Lutathera (177Lu-DOTATATE) recently gaining approval in patients with mCRPC and GEP-NETs respectively. As a new and emerging modality there is still a lot to learn about how RLTs engage with the tumor and modulate its stromal microenvironment.
Preferred start date: as soon as possible (negotiable)
Duration: 36 to 48 months
Location: Novartis Campus, Basel, Switzerland
Key responsibilities
As a Discovery Fellow, you will:

- Actively design and shape the research project.
- Design and implement in vivo studies with syngeneic tumor models. Carry out ex vivo analysis of tumors by flow cytometry using large lymphoid/myeloid panels, single cell RNA Seq, IHC/IF etc.
- Implement reductionist in vitro assays of CAF and immune cell function.
- Work closely with data sciences to inform research questions and experiments.
- Collaborate with Novartis researchers and academic partners.
- Present at lab meetings, internal seminars and international conferences.
- Publish research findings in leading peer-reviewed journals.

LI-Onsite

PDX

**Commitment to Diversity & Inclusion**:

- We are committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve._

**Role Requirements**

Role Requirements:

- Hands on experience with in vivo tumor models and ex vivo analysis by flow cytometry.
- Substantial experience with standard in vitro cell biology techniques (cell culture, lenti/retroviral infection, western blot, IF, qPCR etc).
- Experience working with radioisotopes is highly desirable though not essential.
- Strong publication record or other scientific achievements (i.e. awards, patents, grants)
- Excellent analytical, communication, presentation and organizational skills
- Passion for fundamental exploratory research and boundless curiosity

How to apply
Please submit your CV and cover letter by April 15 for consideration. Please make sure to discuss in the cover letter how this training program will help you fulfill your career goals.
Why Novartis:

Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable

**Division**

Biomedical Research

**Business Unit**

Oncology NIBR

**Work Location**

Basel

**Company/Legal Entity**

Novartis Pharma AG

**Functional Area**

Interns/Students on Novartis Payroll

**Job Type**

Full Time

**Employment Type**

Internship

**Shift Work**

No

**Early Talent**

Yes

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