Phd Position in Pediatric Tumor Nanoparticle

vor 4 Wochen

Bern, Schweiz Insel Gruppe Vollzeit

Medical division for children and adolescents
University Clinic for Pediatrics
Pediatric Hematology Oncology

100 % | in Bern
Entry per 01.03.2023 or by agreement
Limited for 3 years

A Postdoc position is available in pediatric tumor nanoparticle targeting in the research group of Prof. Rössler and PD Dr. Bernasconi at the Department of Pediatric Hematology & Oncology of the INSELSPITAL, University Hospital Bern, Switzerland.

PhD in pediatric tumor targeting with nanoparticles
Many who survive childhood cancer experience treatment complications as adults. One of the biggest challenges of treating children with cancer is achieving complete remission, while ensuring that they will be able to lead normal, productive life in adulthood. In particular we focus on rhabdomyosarcoma, the most frequent the pediatric soft tissue sarcoma. Our aim is to improve existing therapies by delivering drugs specifically to the tumor or its vasculature, thereby reducing late effects and increasing the efficacy of the treatments. We have identified specific rhabdomyosarcoma binding peptides. Recently, we have been establishing the optimal conditions to formulate two types of nanoparticles: liposome and silica-nanotubes loaded with chemotherapeutics and decorated with targeting moieties.

One aim of the project is to assess in vivo targeting of nanoparticles to RMS tumors and quantify the biodistribution and therapeutic potential by quantitative and qualitative approaches. A further aim of the project is to investigate the mechanisms of cellular uptake of the targeted nanoparticles, focusing in particular on the biological and mechanistic role of the targeted cell surface molecules.

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    vor 2 Monaten

    Bern, Schweiz Universität Bern Vollzeit

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