Global Head, Immunology Translational Medicine

Vor 2 Tagen

Basel, Schweiz Novartis Vollzeit

10 That’s how many pipeline projects Immunology has in Phase 3 or registration and over 25 projects in Phase 1/2. Immunology is a key area for Novartis, and one where we have a long tradition. From the launch of Sandimmune (cyclosporin) 30 years ago to enable solid organ transplantation, to the current blockbusters Ilaris (anti-IL-1) and Cosentyx (anti-IL-17), Novartis has long had a focus on treating immunological diseases in rheumatology, dermatology, organ transplant, and autoimmune diseases. And we’re not looking back- Within TM, TM Discovery & Profiling (TMDP) is a group of about 65 physicians and clinical researchers who drive that innovative science from discovery to the patient through the selection, profiling, and effective development of medicines. Translational Medicine Experts (TME’s) oversee Phase 1 and 2 clinical trials to demonstrate proof of concept in patients, creating the case for drugs to proceed to late-stage development and registration. TME’s are also responsible for Phase 3 clinical pharmacology and mechanistic studies. Overall, TM and NIBR deliver about half of the final drug dossier or label information.
- As the Global Head TM Immunology, you will lead a team of TME’s responsible for all early clinical development plans and studies through Proof of Concept, new disease indications, translational research and profiling activities, and clinical pharmacology studies for the Immunology Therapeutic Area. You will be a member of the global Translational Medicine Leadership Team, accountable for overall department goals, helping to lead continuous improvement across the department, and enhancing the culture of TM. You will also be a key bridge between Immunology Research and late phase development and commercial colleagues across the Immunology Franchise in Novartis.
- Your major accountabilities will be to:
- Set, communicate and drive strategy for the Immunology Translational Medicine Therapeutic Area in alignment with the broader organization
- Be accountable for setting the biomarker strategy for your group
- Prioritize and allocate resources across the team to meet portfolio needs
- Co-chair the Disease Area Decision Board with the Research Disease Area Head to decide on targets, compounds, and indications to progress from preclinical ideas to clinical testing
- Deliver clear human Proof-of-Concept study outcomes for decisions on new compounds
- Collaborate with Development colleagues to agree on Proof-of-Concept criteria and indications and on Development Decision Point criteria
- Support Translational Medicine Experts on Development teams after Proof-of-Concept to deliver clinical pharmacology and mechanistic studies
- Bring relevant internal and external opinion leaders together to consider the proposed approach to Clinical Proof-of-Concept
- Foster strong external clinical collaborations to maintain state of the art clinical approaches
- Contribute senior level expertise to Strategic Alliances, Business Development and Licensing due diligence reviews for in licensing and out licensing opportunities
- Provide or review Translational Medicine input to meetings and interactions with Health Authorities
- Develop talent pipeline through recruitment activities and being a mentor, coach, and educational resource across Novartis responsible for quality of clinical protocols, study reports and submission documents

The position is based in Basel, Switzerland and will require 25% travel as defined by the business (domestic and/or international). We support international family relocation and integration support to Switzerland.**Commitment to Diversity & Inclusion**:

- Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve._

**Minimum requirements**
- What you will bring to this role:
**Education**:
- MD or MD/PhD, or MD with doctoral thesis in relevant field (Rheumatology, Allergy & Immunology, Transplantation, or related field)

Board certification in a relevant field. Subspecialty clinical training in Immunology disorders (preferred) or related subspecialty with appropriate Board Certification(s)
- Languages:
- Fluent English, strong written and oral communication skills

**Experience**:
- Leadership position in pharmaceutical/biotech industry or academic medical center combining scientific and medical subspecialty skills, maintaining state-of-the-art clinical approaches and inspiring a culture of continuous improvement, innovation and quality
- Significant clinical experience with patients with Immunology diseases
- Direct basic science expertise within Immunological diseases: accomplished independent basic investigator, recognized in your field through peer-reviewed grant funding, publications and congresses
- Strategic thinker, used to creating major innovations, networking with leading investigators, presenting complex strategic issues in a clear and logical way and driving

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