Phd Student
vor 2 Wochen
The Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major challenges facing society, science and economy. PSI is committed to the training of future generations. Therefore, about one quarter of our staff are post-docs, post-graduates or apprentices. Altogether, PSI employs 2200 people.- **PhD Student****:
**Your tasks**:
- Evaluate metal elements, metallic nanoparticles in postmortem brain tissues of individuals with neurodegenerative diseases by using X-ray microspectroscopy and energy SEM-dispersive X-ray (EDX) analysis
- Investigate how amyloid proteins, particularly Alzheimer's Aβ and Parkinson's α-synuclein, induce the formation of metallic nanoparticles in coacervation through the use of biophysical techniques such as NMR spectroscopy and Xray absorption spectroscopy
- Characterize the cellular toxicity and potentially harmful effects of metallic nanoparticles and metal-protein coacervates using cell viability assays and other biochemical assays
- Collaborate with other group members, utilizing the facilities and resources available at the PSI and Biozentrum Basel
- Co-supervise and co-support master and bachelor students
- Present work at international conferences/workshops and publish work
**Your profile**:
- Good background in protein aggregation, amyloid research, or metal-protein interactions
- Experience with biophysical techniques such as NMR spectroscopy or soft X-ray absorption spectroscopy
- Knowledge of neurodegenerative diseases and their molecular mechanisms
- Ability to work independently as well as collaboratively in a multidisciplinary team
- Excellent communication and scientific writing skills
**We offer**:
Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.
For further information, please contact Dr Jinghui Luo, phone +41 56 310 47 64.-
Paul Scherrer Institut, Human Resources Management, Luca Simen, 5232 Villigen PSI, Switzerland
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