Internship at The Interface of Biomedical
Vor 2 Tagen
The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated **Intern** to take part of a medical device development in the context of gene therapy within the Ophthalmic Translational Research Group.
IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.
The Ophthalmic Translational Research Group is primarily interested in** gene therapy with focus on vision loss**. The eye as a model system provides a unique opportunity to study, develop and translate novel classes of therapies (such as optogenetics, pre-cision genome editing or RNA therapy). Due to its small size and relative immunprivi-leged environment, a new concept can rapidly reach the stage of a first-in-human (FIH) clinical trial. IOB currently has two main preclinical programs based on gene therapy (cone-based optogenetic vision restoration and base editing for Stargardt dis-ease).
In this project, we aim to develop a novel surgical device that would allow to deliver gene-based medicines into specialized compartments of the eye. The device has a clear translational pathway as it will be used in IOB's gene therapy programs. The de-vice is co-developed by IOB's researchers and a Swiss engineering company.
**Your position**
- Work together with engineers, researchers and medical doctors to develop the surgical instrument
- Build an experimental test setup to determine the critical biophysical parame-ters of injection
- Perform experiments on ex vivo model systems (e.g. porcine eyes) to ana-lyze critical parameters for developing the surgical instrument
- Design and develop the core elements of the surgical device and perform proof-of-concept experiments on ex vivo model systems
- Be part of the translation of the device to the clinic
**Your profile**
- BSc or MSc degree in the field of Biomedical Engineering, Biotechnology, Bi-ophysics or similar field
- Programming skills for data analysis (e.g. MatLab, R, python etc.)
- Ability and willingness to work in a Team
**We offer you**
- Highly competitive conditions in a dynamic and international research com-munity in Basel
- Work with an interdisciplinary Team consisting of engineers, researchers and medical doctors
- IOB is an equal-opportunity employer with family-friendly work policies
**Application / Contact**
- CV detailing scientific experience, publications, acquired skills
- A detailed description of your long-term research interests, research ideas and career goals
- ideally contact information for two (2) references
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