Dmpk/ Pd Data Scientist

vor 6 Monaten

Basel, Schweiz Work Selection Vollzeit

**Beschreibung**:
For our international medical partner, F. Hoffmann-La Roche Ltd. in Basel, we are looking for a qualified and motivated **DMPK/ PD Data Scientist** for a temporary contract of 12 months.
- and back-end IT infrastructure related to planning, execution, analysis, and database curation of non-clinical pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PKPD) studies.

**Tasks**:

- Support of non-clinical PK and PKPD studies.
- Support front
- and back-end IT infrastructure related to planning, execution, analysis, and database curation of non-clinical pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PKPD) studies.
- Development of standardized PK protocols with external collaborators (CROs) to reduce turnaround time.
- Validation of external PK reports in collaboration with internal stakeholders and study monitors.
- Support tools and work as PK customer representative for automated data analysis and prediction tools such as integrated high throughput PBPK models.
- Integration of available in vitro and in vivo non-clinical data. Integration and visualization of available data within databases and maintenance of software used by drug discovery teams (e.g. D360, Spotfire).
- Liaise data analysis workflows with other functions such as PBPK modeling approaches., machine learning (ML) models and PKPD models (built in R, Berkeley-Madonna, Phoenix WinNonlin, Monolix, Morphit).
- Automation of TK analysis and reporting

**Must Haves**:

- Min. 1-2 years experience in programming (e.g. Python, R, C++, Java, SQL)
- Ability to perform PBPK analysis
- Fluent in English
- Experience in machine learning, chemoinformatics, computational chemistry, biology, or toxicology is a plus
- Experience in pharmaceutical industry, pharmacokinetic evaluation or drug discovery/development is a plus
- Experience in a GMP regulated environment is a plus

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