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Depicting Novel Cytokine and Transcriptional Axis
vor 3 Monaten
**Depicting novel cytokine and transcriptional axis governing CD8 T cell exhaustion: Implications for Cancer Immunotherapy**:
- Réf **ABG-120798**
- Sujet de Thèse- 01/03/2024- Financement public/privé- Department of Biomedicine, University of Basel- Lieu de travail- Basel - Suisse- Intitulé du sujet- Depicting novel cytokine and transcriptional axis governing CD8 T cell exhaustion: Implications for Cancer Immunotherapy- Champs scientifiques- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- CD8 T cell exhaustion, Cancer Immunotherapy, PD-1, Checkpoint blockade, Murine models, single-cell omics, CRISPR.**Description du sujet**:
Prof. Beltra’s group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers. Notably, we are particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation. Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking. By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy). To this end, we have developed relevant murine models for the study of CD8 T cell-exhaustion and are leveraging cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), to identify and characterize new pathways of interest for a better therapeutic manipulation of exhausted CD8 T cells. Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.
As part of your Ph.D. project you will be in charge of depicting the impact of key cytokine and transcriptional axis on the process of CD8 T cell exhaustion and evaluate therapeutic opportunities for manipulating these axis in combination to PD-1 blockade.
- Your position- Planning, designing, and executing experiments including experiments involving mice.
- Analyzing, structuring, and presenting data.
- Handling mouse colonies and developing original transgenic mouse strains.
- Participating in common lab tasks.
- Preparation of scientific reports, meetings, and journal articles.
- Communicating science at local and international meetings.
**Nature du financement**:
- Financement public/privé**Précisions sur le financement**:
- 4 years**Présentation établissement et labo d'accueil**:
- Department of Biomedicine, University of Basel- The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University. We are located in the heart of Basel across 6 different locations. Be part of our future-
**Intitulé du doctorat**:
- Ph.D. Immunology**Pays d'obtention du doctorat**:
- Suisse**Etablissement délivrant le doctorat**:
- University of Basel
-**:
- M.Sc. in Immunology, cancer immunobiology, biomedical science, genetics or related fields.
- Strong interests in immunology, cancer immunobiology and/or cancer immunotherapy.
- Proficient with basic lab techniques (cell culture, working in sterile conditions).
- Previous experience in flow cytometry, immunological techniques, and mouse work (handling, injections, tissue harvest).
- Knowledge in molecular biology and sequencing data analysis is considered a plus.
- Excellent written and communication skills.
- Fluency in French or English - _required_.
