Internship – DNA ENCODED LIBRARIES

Vor 3 Tagen

Zürich, Schweiz Philochem AG Vollzeit

Job Title: Internship – DNA ENCODED LIBRARIES (DELs)

Department: Others

Who we are

Philogen is a Swiss-Italian integrated biotechnology company founded in 1996, with the mission to develop innovative biopharmaceuticals for targeted therapy (http://www.philogen.com). Philochem AG is the R&D department of Philogen, located in Otelfingen (Zurich, Switzerland).

Philochem AG is seeking a highly motivated and collaborative intern to join our DNA-Encoded Library (DEL) team. We focus on creating innovative DELs designed to identify selective protein binders of pharmaceutical interest, with a particular emphasis on applications in tumor targeting. The successful candidate will be responsible for designing, synthesizing, and screening libraries against protein targets. Additionally, they will re-synthesize hit candidates identified from high-throughput screening (HTS) campaigns.

Key tasks and responsibilities

  1. Teaming up with the laboratory manager to ensure good work organization;
  2. Design and plan scientific projects related to R&D (synthesis of new DELs);
  3. Synthesize, purify, and characterize small molecule-oligonucleotide conjugates (library members) and assemble innovative DNA-encoded libraries (DELs);
  4. Discovery of novel HIT candidates screening our DELs;
  5. Re-synthesize and validate the selected HIT candidates.

Minimum Requirements

  1. A master’s Degree in Chemistry or Medicinal Chemistry. Candidates with a PhD will not be considered for this position.
  2. Experience with organic chemistry and organic synthesis of small molecules.
  3. Experience with small molecule purification and characterization (HPLC, LC-MS, NMR).
  4. Experience with DEL synthesis and screening is a plus.
  5. Experience with peptide synthesis is a plus.
  6. Experience with protein production and purification is a plus.
  7. Experience with analytical chemistry.
  8. Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.
  9. Strive for scientific excellence and attention to detail while being pragmatic.
  10. Ability to see the big picture and strategic thinking.
  11. Strong team player with curiosity for the view of others.
  12. Fluency in oral and written English is a must.

Interested candidates are kindly asked to send their Curriculum Vitae to the following e-mail address jobopportunities@philogen.it, specifying the job position of interest.

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