PhD Position in Normal Tissue Radiobiology of Spatially Fractionated Radiation Therapy

vor 20 Stunden

Bern, Schweiz University of Bern Vollzeit
The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research groups. These groups focus on biomedical research in diverse fields such as Developmental Biology and Regeneration, Immunobiology, Angiogenesis, Cancer, and Spatially Fractionated Radiation Therapy.
Dr. Cristian Fernandez-Palomo is offering an exciting opportunity for a PhD candidate to join our interdisciplinary team and work on normal tissue toxicity in sub-millimeter Spatially Fractionated Radiotherapy (sub-mm SFRT) as part of the MIRACLE project. Sub-mm SFRT is an innovative radiotherapy technique that uses spatially modulated radiation beams, including microbeams and minibeams, at sub-millimeter scales. This method creates distinct regions of high and low doses (peaks and valleys), enabling precise tumor targeting while preserving surrounding healthy tissues. Moreover, sub-mm SFRT has the potential to revolutionize radiation oncology by triggering activation of the immune system and inducing unique vascular effects, which contribute to enhanced tumor control and improved normal tissue preservation.
The MIRACLE project, funded by the Swiss National Science Foundation (grant number: 10002984), brings together leading experts in radiation oncology, biology, and medical physics. It aims to translate breakthroughs in microbeam and minibeam radiation therapy into clinically viable systems, leveraging immune activation and vascular modulation to enhance tumor control while protecting healthy tissues. Collaborating with international partners, the project integrates advanced technologies to transform clinical radiotherapy.
Tasks
  • Conduct toxicity studies to establish safe valley and peak dose thresholds for various sub-mm SFRT configurations.
  • Perform acute toxicity assessments in animal models, focusing on skin and vascular responses.
  • Utilize fractionated Conv-RT techniques as a baseline to compare sub-mm SFRT outcomes and establish Biologically Effective Doses (BED).
  • Investigate dose-response relationships by conducting systematic dose escalation studies for valley and peak doses.
  • Collaborate with experts in radiation biology, medical physics, and clinical oncology to translate sub-mm SFRT into therapeutic applications.

Requirements
  • Master's degree in biomedical sciences, molecular biology, biology, biochemistry, immunology, radiation biology, genetics or related discipline.
  • Experience working with in mice models is a must.
  • Experience working with the Chick Chorioallantoic Membrane (CAM) model is desired.
  • Experience working with radiation is highly desired.
  • Experience with normal tissue radiotoxicity is highly desired.
  • Experience studying vascular effects in general is desired.
  • Proficiency in laboratory techniques including histopathological analysis, cytokine profiling, functional assays, immunohistochemistry, and imaging techniques for tissue damage assessment.
  • Proficiency in English as it will be the main language of communication.
  • Speaking German is an asset.

We offer
  • A fully funded 4-year PhD position with a competitive salary based on the Swiss National Science Foundation scale (www.snf.ch).
  • An inspiring and supportive research environment with state-of-the-art facilities and opportunities for collaboration and continuous education.
  • The chance to present your results at international conferences.
  • Engagement in an interdisciplinary, international, and dynamic team comprising biologists, physicists, and medical doctors.
  • A safe, inclusive, and supportive research environment that values diversity and welcomes minorities.
  • Equal opportunities provided by the University of Bern, with a strong commitment to diversity and excellence.

Interested?

For further questions regarding the position, please contact Dr. Cristian Fernandez-Palomo (cristian.fernandez@unibe.ch).


Application Package
Only complete applications, with the following documents, will be considered:
1. Curriculum Vitae, including list of publications.
2. Letter of Motivation, detailing your suitability for this position. Focus on describing your previous research experience, including an overview of your techniques, methods that you have used in previous research work.
3. Copy of master's degree Certificate.
4. Two reference letters.

#J-18808-Ljbffr

  • Phd Position in Normal Tissue Radiobiology of Spatially Fractionated Radiation Therapy

    vor 4 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research...

  • PhD Position in Tumor Radiobiology of Spatially Fractionated Radiation Therapy

    vor 19 Stunden

    Bern, Schweiz University of Bern Vollzeit

    The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research...

  • Phd Position in Tumor Radiobiology of Spatially Fractionated Radiation Therapy

    vor 4 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research...

  • Postdoctoral Position in Spatially Fractionated

    vor 2 Wochen

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **Postdoctoral Position in Spatially Fractionated Radiation Therapy** **100%**: The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has a teaching assignment in the study programmes of Human Medicine and Dentistry, as well as Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Eleven independent but...

  • Postdoctoral Position in Spatially Fractionated

    vor 7 Monaten

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **Postdoctoral Position in Spatially Fractionated Radiation Therapy** **100%**: The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has teaching responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Ten independent but highly...

  • Postdoctoral Position in Spatially Fractionated

    vor 2 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has a teaching assignment in the study programmes of Human Medicine and Dentistry, as well as Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Eleven independent but highly cooperative working groups conduct biomedical research in the fields of...

  • Postdoctoral Position in Spatially Fractionated

    vor 7 Monaten

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has teaching responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Ten independent but highly collaborative working groups conduct biomedical research in the fields of Didactic...

  • Phd Position

    vor 1 Woche

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD position** **Interpretability-Guided Deep Learning for Medical Image Analysis: Applications to Medical Image Classification, Retrieval and Segmentation**: Your job: In this project supported by the Swiss National Science Foundation, your role is to research innovative ways to employ information stemming from interpretability methods used in deep...

  • Phd Student Position in Cell Biology

    vor 7 Monaten

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD student position in Cell Biology** **100 %**: Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland starting date upon agreement The research of the Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland answers clinically oriented...

  • PhD position in Digital Pathology

    vor 19 Stunden

    Bern, Schweiz University of Bern Vollzeit

    RESEARCH FIELDS:Computational Biology, Bioinformatics, Systems Biology, or a STEM-related field, such as Mathematics, Physics, Computer Science.RESEARCHER PROFILE:Doctoral Candidate (i.e. not already in possession of a doctoral degree at the date of the recruitment)APPLICATION DEADLINE:30 January 2025LOCATION:University of Bern (Switzerland)TYPE OF...

  • Phd Student Position in Cell Biology

    vor 8 Monaten

    Bern, Schweiz Universität Bern Vollzeit

    Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland starting date upon agreement The research of the Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland answers clinically oriented mechanistic questions related to oral hard and soft...

  • Two PhD Positions in Philosophy, University of Bern

    vor 20 Stunden

    Bern, Schweiz University of Bern Vollzeit

    Institute of Philosophy, University of BernStart of employment: 01.03.2025 or by agreementEmployment is fixed-term for 4 years.The Institute of Philosophy at the University of Bern offers two PhD positions within the project "Worldly Indeterminacy", which is funded by an SNSF Consolidator grant. The working hypothesis of this project is that there are facts...

  • PhD Position in Sub-Seasonal Predictability of Extreme Storm Impacts

    vor 19 Stunden

    Bern, Schweiz University of Bern Vollzeit

    Institute of Geography, University of BernThe position is available from April 2025 earliest and offered for 3.5 years (renewable to max. 4 years). We invite applications for a PhD position in the field of Atmospheric Sciences at the Institute of Geography and Oeschger Centre, University of Bern. The project, funded by the Swiss National Science Foundation,...

  • Phd Position

    Vor 7 Tagen

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD Position**: Applications are invited for a PhD position available at the Department for BioMedical Research, Oncology - Thoracic Malignancies Research Program, (PD Dr. Thomas M. Marti Lab), University of Bern, Switzerland One PhD position is available to investigate how modulation of the lactate metabolism mechanisms affects the response of cancer...

  • Phd Position

    Vor 7 Tagen

    Bern, Schweiz Universität Bern Vollzeit

    Applications are invited for a PhD position available at the Department for BioMedical Research, Oncology - Thoracic Malignancies Research Program, (PD Dr. Thomas M. Marti Lab), University of Bern, Switzerland One PhD position is available to investigate how modulation of the lactate metabolism mechanisms affects the response of cancer cells to radio We...

  • PhD position: Population genomics of wild rodents and their microbes

    vor 19 Stunden

    Bern, Schweiz University of Bern Vollzeit

    University of Bern, Institute of Ecology and Evolution, Bern, SwitzerlandA funded PhD position is available for research on the genomic consequences of population isolation, speciation and hybridization and their feedback on associated microbes. This will contribute to answering fundamental questions such as: What is the importance of adaptive and neutral...

  • Phd Position Geochemistry

    vor 9 Monaten

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD position geochemistry**: One PhD position is available in Isotope Geology at the Institute of Geological Sciences at the University of Bern. This PhD project will focus on sublithospheric diamonds and ultradeep xenoliths from the Jagersfontein kimberlite, South Africa. Through constraining the nature and variation of compositions of this material -...

  • Phd Position in Cardiac Stem Cell Biology

    Vor 4 Tagen

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD Position in Cardiac Stem Cell Biology**: The research group of PD Dr. Nina Ullrich at the Institute of Physiology of the Medical Faculty of the University of Bern, Department of Cardiac Physiology, is offering a new position for a PhD student in the field of: **Structural and functional maturation of stem cell-derived cardiomyocytes** You will join a...

  • PhD positions in Machine Learning and Medical Imaging

    vor 3 Wochen

    Bern, Schweiz University of Bern Vollzeit

    The Artificial Intelligence in Medical Imaging (AIMI) lab at the University of Bern's ARTORG Center for Biomedical Engineering Research invites applications from excellent scientists and engineers with a strong background in machine learning and computer vision to work on innovative methods in the domains of medical image computing.We are looking for...

  • Phd Position in Organs-on-chip

    Vor 4 Tagen

    Bern, Schweiz Universität Bern Universität Bern Vollzeit

    **PhD Position in Organs-on-Chip** **development of next generation lung-on-chip system**: Are you looking for a PhD position that will allow you to develop cutting-edge technologies and work at the forefront of personalized medicine? Our team is looking for a highly motivated and talented PhD student to help us develop next generation organs-on-chips (OOC)...