PhD Position in Normal Tissue Radiobiology of Spatially Fractionated Radiation Therapy

vor 4 Wochen

Bern, Schweiz University of Bern Vollzeit
The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research groups. These groups focus on biomedical research in diverse fields such as Developmental Biology and Regeneration, Immunobiology, Angiogenesis, Cancer, and Spatially Fractionated Radiation Therapy.
Dr. Cristian Fernandez-Palomo is offering an exciting opportunity for a PhD candidate to join our interdisciplinary team and work on normal tissue toxicity in sub-millimeter Spatially Fractionated Radiotherapy (sub-mm SFRT) as part of the MIRACLE project. Sub-mm SFRT is an innovative radiotherapy technique that uses spatially modulated radiation beams, including microbeams and minibeams, at sub-millimeter scales. This method creates distinct regions of high and low doses (peaks and valleys), enabling precise tumor targeting while preserving surrounding healthy tissues. Moreover, sub-mm SFRT has the potential to revolutionize radiation oncology by triggering activation of the immune system and inducing unique vascular effects, which contribute to enhanced tumor control and improved normal tissue preservation.
The MIRACLE project, funded by the Swiss National Science Foundation (grant number: 10002984), brings together leading experts in radiation oncology, biology, and medical physics. It aims to translate breakthroughs in microbeam and minibeam radiation therapy into clinically viable systems, leveraging immune activation and vascular modulation to enhance tumor control while protecting healthy tissues. Collaborating with international partners, the project integrates advanced technologies to transform clinical radiotherapy.
Tasks
  • Conduct toxicity studies to establish safe valley and peak dose thresholds for various sub-mm SFRT configurations.
  • Perform acute toxicity assessments in animal models, focusing on skin and vascular responses.
  • Utilize fractionated Conv-RT techniques as a baseline to compare sub-mm SFRT outcomes and establish Biologically Effective Doses (BED).
  • Investigate dose-response relationships by conducting systematic dose escalation studies for valley and peak doses.
  • Collaborate with experts in radiation biology, medical physics, and clinical oncology to translate sub-mm SFRT into therapeutic applications.

Requirements
  • Master's degree in biomedical sciences, molecular biology, biology, biochemistry, immunology, radiation biology, genetics or related discipline.
  • Experience working with in mice models is a must.
  • Experience working with the Chick Chorioallantoic Membrane (CAM) model is desired.
  • Experience working with radiation is highly desired.
  • Experience with normal tissue radiotoxicity is highly desired.
  • Experience studying vascular effects in general is desired.
  • Proficiency in laboratory techniques including histopathological analysis, cytokine profiling, functional assays, immunohistochemistry, and imaging techniques for tissue damage assessment.
  • Proficiency in English as it will be the main language of communication.
  • Speaking German is an asset.

We offer
  • A fully funded 4-year PhD position with a competitive salary based on the Swiss National Science Foundation scale (www.snf.ch).
  • An inspiring and supportive research environment with state-of-the-art facilities and opportunities for collaboration and continuous education.
  • The chance to present your results at international conferences.
  • Engagement in an interdisciplinary, international, and dynamic team comprising biologists, physicists, and medical doctors.
  • A safe, inclusive, and supportive research environment that values diversity and welcomes minorities.
  • Equal opportunities provided by the University of Bern, with a strong commitment to diversity and excellence.

Interested?

For further questions regarding the position, please contact Dr. Cristian Fernandez-Palomo (cristian.fernandez@unibe.ch).


Application Package
Only complete applications, with the following documents, will be considered:
1. Curriculum Vitae, including list of publications.
2. Letter of Motivation, detailing your suitability for this position. Focus on describing your previous research experience, including an overview of your techniques, methods that you have used in previous research work.
3. Copy of master's degree Certificate.
4. Two reference letters.

#J-18808-Ljbffr

  • PhD Position in Tumor Radiobiology of Spatially Fractionated Radiation Therapy

    vor 4 Wochen

    Bern, Schweiz University of Bern Vollzeit

    The Institute of Anatomy at the University of Bern is part of the Faculty of Medicine and plays a pivotal role in research and education. With responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine, the institute hosts ten independent but highly collaborative research...

  • Postdoctoral Position in Spatially Fractionated

    Vor 6 Tagen

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has a teaching assignment in the study programmes of Human Medicine and Dentistry, as well as Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Eleven independent but highly cooperative working groups conduct biomedical research in the fields of...

  • Postdoctoral Position in Spatially Fractionated

    Vor 4 Tagen

    Bern, Schweiz Universität Bern Vollzeit

    The Institute of Anatomy of the University of Bern is part of the Faculty of Medicine and has teaching responsibilities in the study programmes of Human Medicine, Dentistry, Pharmaceutical Sciences, Biomedical Engineering, and Veterinary Medicine. Ten independent but highly collaborative working groups conduct biomedical research in the fields of Didactic...

  • PhD Positions at the Center for AI in Radiation Oncology in

    Vor 7 Tagen

    Bern, Schweiz INSELSPITAL Vollzeit

    PhD Positions at the Center for AI in Radiation Oncology in (pediatric) digital oncologyEntry Spring 2025 or upon agreement temporary for 4 yearsThe new Center for AI in Radiation Oncology (CAIRO) within the Inselspital and affiliated with the University of Bern will investigate data-driven solutions for radiation oncology applications in the context of...

  • Phd Position

    vor 2 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    Your job: In this project supported by the Swiss National Science Foundation, your role is to research innovative ways to employ information stemming from interpretability methods used in deep learning to jointly improve model training, performance, and model interpretability. Through this new learning paradigm, we expect to make contributions to fighting...

  • Phd Student Position in Cell Biology

    vor 1 Woche

    Bern, Schweiz Universität Bern Vollzeit

    Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland starting date upon agreement The research of the Laboratory of Oral Cell Biology at the Department of Oral Surgery and Stomatology, University of Bern, Switzerland answers clinically oriented mechanistic questions related to oral hard and soft...

  • Two PhD Positions in Philosophy, University of Bern

    vor 4 Wochen

    Bern, Schweiz University of Bern Vollzeit

    Institute of Philosophy, University of BernStart of employment: 01.03.2025 or by agreementEmployment is fixed-term for 4 years.The Institute of Philosophy at the University of Bern offers two PhD positions within the project "Worldly Indeterminacy", which is funded by an SNSF Consolidator grant. The working hypothesis of this project is that there are facts...

  • PhD positions in Machine Learning and Medical Imaging

    vor 4 Wochen

    Bern, Schweiz University of Bern Vollzeit

    The Artificial Intelligence in Medical Imaging (AIMI) lab at the University of Bern's ARTORG Center for Biomedical Engineering Research invites applications from excellent scientists and engineers with a strong background in machine learning and computer vision to work on innovative methods in the domains of medical image computing.We are looking for...

  • Phd Student

    Vor 4 Tagen

    Bern, Schweiz Insel Gruppe Vollzeit

    Medical division cancer Department of Medical Oncology 100 % | in Bern Entry per immediately or by agreement Limited for 3 years Our research group studies epigenetic regulators in blood and patient-derived cancer tissue, focusing on Lung and Head and Neck cancers. We have ongoing clinical trials in which we are identifying new epigenetic biomarkers for...

  • PhD student position in Pharmaceutical Technology

    Vor 4 Tagen

    Bern, Bern, Schweiz University of Bern Vollzeit

    One Ph.D. position is available in the research group of Prof. Luciani at the University of Bern on the topic "In vitro models of fibrosis in endometriosis as a screening tool for novel and repurposed drug candidates". The planned starting date is August 1, 2025.Background:Endometriosis is a chronic condition that is estimated to affect 5–10% of women of...

  • Phd Position

    vor 2 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    **The project** **The Ph.D. Position** On the teaching side, she/he will work as teaching assistant in courses at either bachelor or master level, helping in the preparation of teaching materials and tutoring students. Fluent German is required for supervising bachelor level courses and laboratory practicals. - Master of Science (MSc) degree - Interest in...

  • Two Phd Positions in Philosophy, University of Bern

    vor 2 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    Institute of Philosophy, University of Bern Start of employment: 01.03.2025 or by agreement Employment is fixed-term for 4 years. The Institute of Philosophy at the University of Bern offers two PhD positions within the project "Worldly Indeterminacy", which is funded by an SNSF Consolidator grant. The working hypothesis of this project is that there are...

  • Postdoctoral Research Position: Spatio-temporal

    Vor 7 Tagen

    Bern, Schweiz Universität Bern Vollzeit

    80-100% The division of Conservation Biology investigates the mechanisms involved in the degradation of ecosystems and in the decline of threatened species with the aim to propose sound conservation guidance for stopping biodiversity erosion, restoring wildlife populations and reinstating functional ecological communities and key ecosystem services. In one...

  • PhD position in Digital Pathology

    vor 4 Wochen

    Bern, Schweiz talendo AG Vollzeit

    Balancing Passion and Profession: Insights from...Dive into their inspiring journeys as they share tips on balancing work and personal interests.Amavita Chemical & Pharmaceutical IndustryRESEARCH FIELDS: Computational Biology, Bioinformatics, Systems Biology, or a STEM-related field, such as Mathematics, Physics, Computer Science.RESEARCHER PROFILE: Doctoral...

  • PhD position in Digital Pathology

    vor 3 Wochen

    Bern, Schweiz talendo AG Vollzeit

    Balancing Passion and Profession: Insights from...Dive into their inspiring journeys as they share tips on balancing work and personal interests.RESEARCH FIELDS: Computational Biology, Bioinformatics, Systems Biology, or a STEM-related field, such as Mathematics, Physics, Computer Science.RESEARCHER PROFILE: Doctoral Candidate (i.e. not already in possession...

  • PhD studentDepartment of Ophthalmology

    vor 3 Stunden

    Bern, Bern, Schweiz Universität Bern Vollzeit

    Start of employment: 01.01.2025 or by agreement, 3 years The Department of Ophthalmology at the Inselspital is a leading center for state-of-the-art diagnostics, therapy and microsurgery of eye diseases and ophthalmologic emergencies and scientifically associated with the (DBMR) at the University of Bern. The research group Retinal Remodeling (Prof. Dr....

  • PhD position: Population genetics of free-roaming dogs and disease

    vor 4 Wochen

    Bern, Schweiz Universität Bern Vollzeit

    A funded PhD position is available in the group of Gerald Heckel for genomic research on the population structure and connectivity of free-roaming dogs and their viruses. This position is part of a large interdisciplinary project funded by the Swiss National Science Foundation (SNSF) aiming to determine the role of free-roaming dogs in the spread and...

  • PhD / Postdoc Positions in Gut Microbiome & Infection

    vor 1 Woche

    Bern, Schweiz University of Bern Vollzeit

    The Institute for Infectious Diseases performs tasks in teaching and research as well as in diagnostic microbiology in the fields of virology, bacteriology, mycology, parasitology and serological infection clarification. It is the only university institute in Switzerland that combines all microbiological specialties in the field of clinical microbiology...

  • Phd Position in Molecular Cell Biology

    Vor 4 Tagen

    Bern, Schweiz Universität Bern Vollzeit

    Position: PhD Student Topic: Mitochondrial Transcription in Trypanosoma brucei Funding: 3 years, Swiss National Science Foundation (50kCHF starting salary + benefits) Supervisor: Prof. Torsten Ochsenreiter The Institute of Cell Biology at the University of Bern is seeking a highly motivated PhD student to join the lab of Prof. Torsten Ochsenreiter. The...

  • PhD studentDepartment of Ophthalmology, Bern

    vor 3 Wochen

    Bern, Schweiz TN Switzerland Vollzeit

    Social network you want to login/join with:PhD Student - Department of Ophthalmology, BernClient:Location:Job Category:OtherJob Reference:8354f3a6b44fJob Views:9Posted:21.01.2025Expiry Date:07.03.2025Job Description:Start of employment: 01.01.2025 or by agreement, 3 years.The Department of Ophthalmology at the Inselspital is a leading center for...