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PhD studentDepartment of Ophthalmology, Bern

vor 1 Monat


Bern, Schweiz TN Switzerland Vollzeit

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PhD Student - Department of Ophthalmology, BernClient:Location:Job Category:

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Job Reference:

8354f3a6b44f

Job Views:

9

Posted:

21.01.2025

Expiry Date:

07.03.2025

Job Description:

Start of employment: 01.01.2025 or by agreement, 3 years.

The Department of Ophthalmology at the Inselspital is a leading center for state-of-the-art diagnostics, therapy, and microsurgery of eye diseases and ophthalmologic emergencies, scientifically associated with the (DBMR) at the University of Bern.

The research group Retinal Remodeling (Prof. Dr. Volker Enzmann) focuses on the employment of Müller cells, the main macroglia in the retina, as potential candidates for replacing degenerated photoreceptors. We investigate the active modulation of Müller cell transition as a pivotal process during degeneration/regeneration and the treatment of chronic gliosis in mice with anti-fibrotic drugs, as we found similarities to wound healing (fibrosis). Additionally, we have established a human retinal organoid degeneration model to study photoreceptor and glial pathologies and the role of Müller cell response.

Challenges/Project:

The project aims at:

  1. Pathway analysis in animal models with retinal degeneration (laser, sodium iodate)
  2. Investigating cell type-associated differential gene expression
  3. Pharmacological treatment and/or gene editing regarding the identified pathways

The experimental spectrum of the PhD project will include classic methods in molecular and cell biology, as well as in vivo experiments including mice, zebrafish, and iPSC-derived or other cell-based systems. Furthermore, bioinformatic evaluation of the data in collaboration with computer scientists will occur.

Requirements:

Applicants should hold a master's degree in biology, biomedical sciences, or related fields, preferably with background knowledge in neurobiology and/or cell biology. Expertise in working with small animal models and bioinformatics would be advantageous. We are looking for highly motivated, interactive, and team-oriented candidates with a high degree of self-initiative and inventiveness.

We Offer:

The interesting and challenging project will be performed in a dynamic team and a creative research environment with a broad spectrum of methodology and further advanced training opportunities. The applicant will join the Graduate School for Cellular and Biomedical Sciences (GCB) to complement their training.

Application and Contact:

For subject-specific questions and information about the position, please contact Prof. Dr. Volker Enzmann, [emailprotected], +41 31 6328935. Please send your application with the usual documents electronically to the following email address:

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