Postdoctoral Position in Neural Circuit Mechanisms of Aging and Alzheimer's Disease

Postdoctoral Position in Neural Circuit Mechanisms of Aging and Alzheimer's DiseaseThe newly established research group led by Prof. Marc Aurel Busche is currently seeking a highly motivated and ambitious postdoctoral researcher interested in conducting cutting-edge research on the molecular and neural circuit mechanisms underlying early stage Alzheimer's disease and related neurodegenerative diseases. The laboratory utilizes cutting-edge recording techniques, including two-photon calcium imaging, high-density neuropixels electrophysiology, and spatial transcriptomics, alongside computational analyses, to uncover novel disease mechanisms and neural biomarkers of disease progression. Our research integrates findings from model systems with translational human studies (e.g., using MEG/EEG), in close collaboration with the Memory Clinic and Old Age Psychiatry at the University Hospital for Geriatric Medicine Felix Platter, where Prof. Busche serves as a clinical director (Chefarzt). The candidate will also benefit from active collaborations with Prof. Busche's research group at the UK Dementia Research Institute at University College London (buschelab.com) providing opportunities for close scientific collaboration, shared projects, and methodological training between Basel and London. The position offers an outstanding opportunity to actively shape and build the direction and profile of this newly founded laboratory, developing novel and innovative independent lines of research and significantly contributing to the lab's scientific vision.The position:Planning, designing, and performing experiments involving two-photon calcium imaging and in vivo neuropixels electrophysiology in combination with novel behavioral paradigms in mouse models.Applying molecular biology methods including spatial transcriptomics and single-cell RNA sequencing to identify molecular alterations underlying cellular and circuit-level changes.Analyzing large-scale, multimodal datasets using computational and statistical approaches.Developing original research directions that integrate molecular, cellular, and systems neuroscience, actively shaping the group's scientific strategy.Collaborating closely with clinicians and researchers at the University Hospital for Geriatric Medicine Felix Platter to link preclinical findings with translational human studies.Maintaining active scientific exchange and collaboration with the Busche group at the UK Dementia Research Institute at University College London.Mentoring Ph.D. students, supporting daily lab operations, and contributing to a vibrant and productive research environment.Preparing scientific manuscripts, grant applications, and presenting research findings at national and international conferences.RequirementsPh.D. in neuroscience, computational neuroscience, biomedical engineering, physics, computer science, mathematics, or related fields.Demonstrated expertise (peer-reviewed publications) in two-photon calcium imaging and/or neuropixels electrophysiology in vivo (essential).Experience with rodent behavioral assays and stereotactic surgical techniques (essential).Strong analytical and computational skills (Python or MATLAB) for large-scale neuronal dataset analysis (essential).Excellent written and communication skills, with fluency in English (essential).Proven ability to conduct independent research projects and collaborate effectively within interdisciplinary teams.Knowledge or strong interest in aging, Alzheimer's disease, and neurodegeneration is advantageous. #J-18808-Ljbffr