Head of Computational Chemistry
vor 2 Wochen
Head of Computational Chemistry Principal Scientist, Head of Computational Chemistry, Argau Canton , Switzerland, Permanent job The company The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression, purification and engineering, and preferential access to synchrotron and free electron laser beamlines for X-ray analysis and cryo-EM facilities, they characterize the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics. Key tasks and responsibilities Utilize modern molecular modelling methods to support different stages of R&D programs. Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit-to-lead and lead optimization. Design, lead and drive computational studies on projects throughout the several discovery phases and ensure execution on agreed deliverables. Set the vision and strategy for computational chemistry. Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration. Collaborate with external partners on joint drug discovery projects. Present plans and results internally, including at board level, and externally at conferences. Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies. Your qualification MSc / PhD in a relevant scientific discipline (Pharmaceutical Sciences, Chemistry, Computational Chemistry) with a solid foundation in molecular modelling built in a pharma / biotech / CRO setting. Expert knowledge in CADD software packages and modern molecular modelling techniques. Sound knowledge in cutting-edge cheminformatic tools, AI / ML-enabled technologies, and in silico drug design, including both structure- and ligand-based methodologies. Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs, ion-channels and transporters). Mastery of all the theoretical and practical principles of medicinal chemistry and drug design. Broad knowledge of biophysical, biochemical, and cell-based assays used in the early stages of the drug discovery process. In depth understanding of multi-parameter optimization and ability to integrate disease biology, ADME / DMPK and toxicology data to solve complex drug discovery problems. Excellent leadership, management, organizational and team-working skills, and a talent to deliver project milestones within the expected time frame. Demonstrated track record of scientific publications. Benefits You will be working for an innovative company aiming to discover new generation medic You will be working with state-of-art technologies You will be working in a supportive and dynamic team Share options bonus If you are interested, please send a CV. It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence. #J-18808-Ljbffr
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Villigen, Schweiz CK Group VollzeitA rapidly growing biotech company in Villigen, Switzerland is seeking a Head of Computational Chemistry to lead and drive computational studies throughout the discovery phases. The ideal candidate will have an MSc/PhD in a relevant scientific discipline and expertise in molecular modelling and drug discovery. This role offers an opportunity to work with...
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Computational Chemist
Vor 4 Tagen
Villigen, Schweiz leadXpro AG VollzeitAt leadXpro, we are dedicated to advancing drug discovery with a unique focus on membrane proteins, some of the most challenging yet therapeutically relevant drug targets. Combining cutting-edge structural biology, computational chemistry, and biophysical methods, we drive innovation in small-molecule discovery for our partners and internal projects. **Your...
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Villigen, Schweiz PSI Laboratory for Energy Systems Analysis (LEA) VollzeitPostdoctoral Fellow in theoretical and computational modelling of ARPES Join the Light‑Matter Interactions group at the LM Laboratory for Materials Simulations (LMS) of PSI's Center for Scientific Computing, Theory, and Data (CSD). The position is advertised for the “Postdoctoral Fellow in theoretical and computational modelling of ARPES.” The posting...
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Villigen, Aargau, Schweiz Paul Scherrer Institute Vollzeit CHF 50'000 - CHF 60'000 pro JahrPostdoctoral Fellow in theoretical and computational modelling of ARPES Your tasksCarry out research theory of angle-resolved photoemission spectroscopy ARPES Implement new methods in and improve open-source scientific software in the group Perform first-principles simulations of ARPES for materials relevant to orbitronics Identify fingerprints of orbital...
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Postdoc: Theoretical
vor 2 Wochen
Villigen, Schweiz Paul Scherrer Institut VollzeitA leading Swiss research institute is seeking a Postdoctoral Fellow in theoretical and computational modelling of ARPES. The role involves conducting research in angle-resolved photoemission spectroscopy, implementing methods in scientific software, and performing first-principles simulations for orbitronics materials. The ideal candidate will hold a PhD in...
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Postdoc: Theoretical
vor 1 Woche
Villigen, Schweiz PSI Laboratory for Energy Systems Analysis (LEA) VollzeitA leading Swiss research institution seeks a Postdoctoral Fellow in theoretical and computational modelling of angle-resolved photoemission spectroscopy (ARPES). Candidates should possess a PhD in Physics, strong theoretical knowledge in condensed-matter physics, and good programming skills in Fortran and Python. Responsibilities include conducting research,...
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Villigen, Schweiz Paul Scherrer Institut VollzeitThe Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major...
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Phd Students
vor 2 Wochen
Villigen, Schweiz Paul Scherrer Institut VollzeitThe Paul Scherrer Institute PSI is the largest research institute for natural and engineering sciences within Switzerland. We perform cutting-edge research in the fields of future technologies, energy and climate, health innovation and fundamentals of nature. By performing fundamental and applied research, we work on sustainable solutions for major...
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Head of MSAT — Tech Transfer
Vor 3 Tagen
Villigen, Schweiz Lonza VollzeitA leading life sciences company is seeking a Head of MSAT to lead a team of experts in driving tech transfers and ensuring GMP readiness. The ideal candidate will possess an MSc or PhD in a relevant field, solid leadership experience, and significant expertise in aseptic processes. This position offers an agile career in a dynamic environment, along with...
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Villigen PSI, Schweiz Paul Scherrer Institut PSI Vollzeit**Your tasks**: - Development of high-resolution mass spectrometry strategies for better resolution, precision, and compound identification - Development of molecular reaction networks from obtained experimental data - Publishing in international leading scientific journals **Your profile**: - You hold a PhD degree in Chemistry, Biochemistry, Analytical...
