(Senior) Scientist

vor 4 Wochen

Basel, Schweiz F. Hoffmann-La Roche AG Vollzeit

(Senior) Scientist - Cancer Cell Dependencies, Discovery Oncology

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our dedicated people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located within our Discovery Research Units within the Oncology Discovery organization dedicated to the discovery and development of novel cancer therapeutics. We collaborate closely with functions in Therapeutic Modalities, Pharmaceutical Science as well as within the oncology therapeutic area to translate hypotheses into innovative therapeutics.

The Opportunity

As a Scientist Discovery Oncology, you will work within a collaborative team of motivated and scientifically rigorous scientists and associates to conduct preclinical research and advance our clinical and preclinical drug programs in the field of cancer cell biology. You will translate basic research findings into therapeutic strategies, utilizing genetic and pharmacological approaches to understand target mechanisms of action, generate patient stratification strategies and identify rational drug combinations that can be translated into the clinic.

  • Lead internal target identification initiatives and exploratory activities, from initial ideation to nomination of the program and proactively seek out future horizon opportunities and be passionate about the co-creation of new areas of focus.
  • Demonstrate hands-on work i.e. active data generation in the lab. May lead internal and/or external global cross-functional portfolio projects of high strategic impact, coordinate cross-functional efforts to meet long-term project objectives as a matrix leader.
  • Design, execute and analyze/interpret experimental strategies and present research results and methodologies at regular meetings with teams, key stakeholders and/or interact regularly with project leaders, project teams and other research forums. Work collaboratively with scientists and associates across oncology discovery research units to integrate complex data sets including high dimensional ‘omic’ data in pre-clinical settings for target validation and increased understanding of target biology and MoA of therapeutic compounds.
  • Work closely with the External Innovation lead, DLT, broader Discovery and early development groups and TMo to coordinate external innovation activities such as: Ideation, consolidation and prioritization of novel external innovation ideas; landscaping of new potential areas of interest, identification and evaluation of external opportunities, execution of due-diligence activities for external programs.
  • Role model curiosity for working flexibly in new concepts and a matrix environment, take a proactive role in personal growth and scientific development. Enable individual and organizational learning within their teams and across the Discovery organization in order to advance the portfolio and scientific innovation. Thrive in a dynamic, inclusive environment and contribute to building a culture that embraces scientific excellence, accountability, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise.
Who you are
  • PhD or MD/PhD in Molecular or Cellular Biology, Immunology, Pharmacology (or a comparable biological science) with 2+ - 4+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environment. Prior industry experience is preferred.
  • Expertise in techniques used for interrogating key cancer immunotherapy pathways or oncogenic dependencies as evidenced by publication in peer-reviewed journals and/or patents.
  • Experience in cancer drug discovery /translational research and targeting molecular pathways using diverse modalities including large and/or small molecule compounds.
  • Experience in intracellular oncogenic signaling is expected, additional knowledge of transcription factor or tumor suppressor biology, epigenetics or colorectal cancer is viewed as a plus.
  • Collaborative mind-set, capable and eager to work within a matrix organization, collective goal achievement, ability to work in a team environment, good communication skills.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you Every role at Roche plays a part in making a difference in patients’ lives. Apply now and join us in making an impact

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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