Director, API External Manufacturing Lead

ppMadrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. /ppEvery member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. /ppOur success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. /ppTo support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. /ph3Key Responsibilities /h3ulliOwns API supply oversight, execution performance, and continuity planning across external manufacturing partners. /liliAligns demand, capacity, lead times, and inventory strategy into an execution plan and maintains governance routines with sites / CMOs to monitor performance and risk. /liliLeads escalation and resolution of supply-impacting constraints and exceptions and coordinates cross-functional recovery plans. /liliPartners with CMC / MSAT and Quality to manage supply impact of deviations, investigations, changes, and tech transfers. /liliEnsures key planning assumptions, parameters, and documentation remain current to support predictable execution. /li /ulh3Performance Governance Continuity Planning /h3ulliOwn API performance KPIs, governance cadence, and continuity plans across sites / CMOs. /liliAlign capacity and inventory strategy to demand commitments, maintain key planning assumptions / parameters. /liliProduce deliverables such as CMO / site performance scorecards, continuity plans, and quarterly capacity reviews. /li /ulh3Exception Management Recovery /h3ulliLead escalation and resolution for constraints (capacity, materials, quality events), coordinate recovery actions and communications. /liliProvide clear options, trade-offs, and timelines, ensure action ownership and closure. /liliProduce deliverables such as recovery plans, escalation briefs, and decision logs. /li /ulh3Technical / Quality Interfaces /h3ulliPartner with CMC / MSAT / Quality on tech transfers, deviations, and changes, ensure readiness for major milestones. /liliMaintain aligned documentation and governance artifacts supporting reliable execution. /liliProduce deliverables such as readiness trackers and cross-functional dependency maps. /li /ulh3Required Qualifications /h3ulliBS+ (Supply Chain, Engineering, Science, or related) /lili12–15 years in API supply / manufacturing planning and performance management, including issue triage /liliDemonstrated cross-functional coordination and escalation leadership /li /ulh3Preferred Qualifications /h3ulliExperience in pharmaceutical / biotech API manufacturing and multi-CMO governance (preferred) /liliExperience supporting launches, network changes, and long lead-time constraint management /li /ulh3Key Competencies /h3ulliAPI supply oversight, continuity planning, and partner governance, KPI cadence and performance recovery management /liliConstraint management, scenario options, and recovery execution, decision trade-offs, and timely escalation /liliCross-functional leadership, escalation, and executive-ready risk / decision communication /liliInterface management with Quality and CMC / MSAT (deviations, changes, transfers), milestone readiness discipline /liliPlanning assumptions / parameter governance, documentation rigor, and plan-to-execution reliability /li /ulpWe are committed to fostering an inclusive and diverse workplace and do not discriminate on the basis of any legally protected characteristics. /ppMadrigal processes your personal data in connection with its recruitment and talent sourcing activities in accordance with applicable data protection laws. Further information about how your personal data is processed, together with details of your rights and how to exercise them, is available in our Job Applicant Privacy Notice, which is made available to you if you apply through Workday. /ppPlease note that this

job description
is not exhaustive and may evolve over time. /ppOnly shortlisted candidates will be contacted. /ppApplicants must be authorized to work in the country of employment at the time of application. /ppEmployment terms, where applicable, will be governed by relevant collective bargaining agreements. /ppUnsolicited resumes from agencies should not be forwarded to Madrigal. /ppMadrigal will not be responsible for any fees arising from the use of resumes through this source. /ppMadrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. /ppJoin our growing team focused on transforming the treatment of people with liver diseases. /ppMadrigal is an Equal Opportunity Employer. /ppAll employment is decided on the basis of qualifications, merit, and business need. /ppApplicants wi