Aktuelle Jobs im Zusammenhang mit Phd Student - Zürich, Zürich - Children's Hospital Zurich
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PhD Position in Self-Assembled Colloidal Systems
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PhD Student in Computational Chemistry
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Research Scientist in Organofluorine Chemistry
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Research Fellow Position in Dental Materials
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Phd Student
vor 3 Monaten
PhD student
100 % :
We are interested in Hemophagocytic Lymphohistiocytosis (HLH), a group of genetic disorders of lymphocyte cytotoxicity predisposing children and infants to severe multi-system inflammatory syndrome.
Immune stimulation, e.g.following infections, is poorly controlled, leading to excessive activation of T cells and macrophages and a life threatening cytokine storm.
Current treatment, which aims at eliminating or suppressing activated immune cells, followed by hematopoietic stem cell transplantation, is still associated with a mortality of around 30-40%.
Recently, more targeted therapies directed at neutralisation of cytokines, for which we have performed decisive preclinical studies, have been evaluated, but it remains unclear whether they will be sufficient to timely and reliably induce complete remission.
Our aim is to better characterise the molecular pathogenesis of the disease and find novel targetable factors that can tip the balance away from excessive immune stimulation.
We aim to do so in an interdisciplinary manner by combining genomics, high-content imaging, use of repurposed drug libraries, and disease modelling in iPSCs or mouse models.
Your responsibilities:
- Characterise novel genetic causes for HLH
- Develop quantitative tools to visualise the pathophysiology (highcontent microscopy and/or genomics)
- Use drug libraries to shape the molecular and cellular networks involved in the manifestation of the disease phenotype
Your profile:
- University degree (masters) in immunology, systems biology, biomedicine or a related field
- Good knowledge and experience with experimental methods, such as Microscopy, Flow Cytometry, work in cell culture, or similar
- Statistical and programming skills (i.e., Python, Matlab, R, SPSS)
- Good knowledge of written and oral English
- Interest in multidisciplinary research in an international team
- High level of initiative, reliability, and independent learning are very welcome
What we offer:
We offer a job with an exposure to molecular and clinical biology as well as an equal hands-on experience in cutting-edge analytical technologies, especially in Imaging and the image analysis field.
You will be part of a very social group with varied and complementary interests and expertise and a lab at the forefront of clinical research.
Place of work:
August-Forel-Strasse 7, Zürich, Switzerland
