Postdoctoral Position in Immunology/cancer
vor 1 Woche
It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need.
With more than 70 research groups and 900 employees, the Department of Biomedicine is the largest department at the University.
We are located in the heart of Basel across 6 different locations. Be part of our futureProf. Beltra's group is studying the factors governing T-cell differentiation programs in settings of viral infections and cancers.
Notably, our group is particularly interested in identifying new pathways regulating the process of CD8 T cell exhaustion, an hypofunctional program acquired by CD8 T cells exposed to persistent inflammation and antigenic stimulation.
Indeed, CD8 T cell exhaustion represents a central limitation to current anti-cancer immunotherapies and strategies aiming at reversing this process are still lacking.
By exploring the intimate mechanisms regulating CD8 T cell exhaustion, our group aims to identify innovative opportunities to reverse this process and unleash the full potential of current cancer immunotherapies (e.g. PD-1-based therapy).Using state-of-the arts murine models combined to cutting-edge technologies (single cell omics, ATACseq) and innovative immunological and genetic perturbation tools (Retroviruses, CRISPR), our group works on identifying new strategies for a better therapeutic manipulation of exhausted CD8 T cells.
Collectively, our group aims to lay the foundation for advancing next-generation cancer immunotherapies.Your position
- Planning, designing, and executing experiments including experiments involving mice.
- Analyzing, structuring, and presenting data.
- Developing collaborative projects.
- Mentoring Ph.
- Handling mouse colonies and developing original transgenic mouse strains.
- Participating in common lab tasks.
- Preparation of scientific reports, meetings, and journal articles.
- Communicating science at local and international meetings.
Your profile
- Ph.
- Demonstrated expertise (peerreviewed publications) in the fields of immunology, Tcell immunobiology, cancer immunobiology and/or cancer immunotherapy
- Required
- Extensive experience in basic immunology techniques (flow cytometry, Tcell based assays)
- Required
- Trained for mouse work (handling, injections, tissue harvest)
- Required
- Demonstrated expertise using CRISPRbased approaches
- Required
- Proficient with basic lab techniques (cell culture, working in sterile conditions).
- Knowledge in nextgeneration sequencing techniques and data analysis is considered a plus.
- Excellent written and communication skills.
- Fluency in French or English
- Required
We offer you
Application / Contact
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