PhD position to characterize genetic susceptibility to chemicals in environmentally-relevant species
vor 3 Wochen
Project background: Chemical pollution threatens biodiversity of ecosystems, yet we know little about different species’ genetic susceptibility to chemicals. Elucidating genetic susceptibility to chemicals for diverse species is essential to protect genetic variability in ecosystems and determine an ecosystem’s resilience and adaptation potential following chemical exposure. However, lab and field-based methods to assess genetic susceptibility are impossible for all chemicals and species.Therefore, computational methods are necessary to help characterize and predict genetic susceptibility to chemicals for different species in an ecosystem.
Project description: For this project, the PhD candidate will use data integration, analysis, and visualization to characterize and predict genetic susceptibility to chemicals in different species. As a starting point, this project will focus on pesticide-induced neurotoxicity for zebrafish and C. elegans. The PhD candidate will develop a data integration protocol to link existing data on chemical activity, genetic variability, and neurotoxicity endpoints. From these linkages, quantitative risk values will be developed to characterize the likelihood that pesticide-induced neurotoxicity varies in genetically diverse populations, and these risk values and data linkages will be used to analyze similarities and differences in genetic susceptibility across species and pesticide modes of action. This position is purely computational, and is for an individual who enjoys programming or is interested in further developing programming skills.
As the PhD candidate for this project you should have an MSc in environmental sciences, toxicology, bioinformatics, or similar. Experience in programming (R or Python preferred), data analysis, and/or data visualization would be a benefit. Knowledge in genetics would be an additional asset. A strong work ethic, mature teamwork attitude, and good English skills are essential.
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