PhD position in Mechanobiology on the role of the extracellular matrix in signal transduction
vor 1 Monat
Job description
The objective will be to measure reaction rates at the cell surface and pathway activation under various molecular confinement conditions. You will design and fabricate confinement conditions through adhesive patterning of surfaces, microfluidic systems, and 3D cell encapsulation in hydrogels. You will use advanced imaging techniques, as well as molecular and cellular assays to assess pathway activation. Applications to both single cells and 3D cell aggregates are envisaged.
In addition, you are expected to contribute to lab duties, and will have the opportunity to contribute to teaching within the group.
This project contains aspects of cell biology, mechanobiology, biophysics, molecular biosciences, and cell substrate engineering. Throughout the PhD, you will gain expertise in these topics. You will also learn a number of techniques in cell and molecular biology, advanced imaging techniques (using fluorescent reporters, FRET, FCS), fabrication and functionalization of hydrogels, and microfabrication.
Your profile
We are looking for a curious and resourceful individual, with a pronounced taste for interdisciplinary science, and a motivation to answer fundamental questions in mechanobiology.
Academic excellence, a professional work attitude, and a proactive and self-driven work ethic are expected. Moreover, the candidate must be able to fluently communicate in English (oral and written) and be willing to work in a highly interactive international team.
Applicants must hold a MSc degree in Physical Sciences, Life sciences, Bioengineering, or related fields. Good knowledge in cell biology or mechanobiology is preferred, but given the interdisciplinary nature of the project, and the wide scope of techniques that will be used, we are open to a variety of educational backgrounds.
In addition, applicants should have at least 2 of the following specific requirements:
Research experience in cell biology. Experience with fluorescent imaging would be appreciated Research experience with use of hydrogels for cell culture Research experience with engineered cell substrates (2D / 3D). Experience with either microfluidics or micropatterning would be a plusThe position is funded by the SNSF for 4 years, at % employment. The project will be supervised by Dr. Céline Labouesse. The position is subjected to admission to the doctoral program at D-MAVT.
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