Cell Culture Automation Engineer

Vor 3 Tagen

Switzerland PlanlesOuates STELLAR Route de la Galaise Selexis Vollzeit CHF 80'000 - CHF 120'000 pro Jahr
ROLES AND Responsibilities

This position will be dedicated to the Cell Culture Automation department, under the supervision of Senior Scientist

  • Ensure cell culture laboratory activities dedicated to the maintenance of CHO cell lines (passaging, batch/fed batch evaluation, cell banking and expansion, cell line productivity and stability evaluation)
  • Support the implementation of an automated cell cultivation platform involving cutting-edge technologies and best-in-class equipments
  • Understand and execute automation procedures using complex integrated liquid handling platform and custom devices
  • Participate to experimental designs to evaluate and characterize automated process performances using Design of Experiments (DoE)
  • Perform control tests to monitor cell culture parameters through manual and automated processes
  • Identify critical cell culture parameters, address bottlenecks in processes/workflows, participate to troubleshooting activities
  • Participate to the characterization of optimized cell culture processes and execute optimization programs to support process improvement activities
  • Independently plan and execute experiments according to preestablished plans, timelines and priorities
  • Participate to the establishment of protocols and documentation required for process validation and platform certification
  • Provide continuous efforts in developing and implementing innovative technologies, methods and improvements
  • Support in equipment maintenance, interaction with equipment vendors
  • Cooperate with internal team collaborators (CLD, R&D, Operations, Analytics) to troubleshoot biology, process or mechanical errors
  • In a later phase, support global Cell Line Development activities
  • Generate data templates and records. Organize and maintain meticulous records on all conducted experiments
  • Manage data analysis, data visualization, verify data integrity and provide technical reports
  • Present data at team meetings

This position will require engagement to weekend call-outs and operate at distance or on site if necessary.

Qualifications
  • Strong experience in mammalian cell cultivation
  • Advanced experience using DoE software (e.g. MODDE) and Excel VBA is a plus 
  • Experience with lab automated systems is preferred (e.g. Hamilton liquid handler) and automation scheduling software is a plus
  • Experience with Raman spectroscopy is a plus
  • Capacity to generate, manage, analyze, and maintain critical data
  • Understand project timelines and priorities is essential
  • Strong attention to details, time management and organizational skills
  • Ability to work independently and as part as a collaborative team

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