Analytical Chemistry

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections,  where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted, and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop, and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Analytical Research & Development department is a key part of Synthetic Molecules Technical Development, globally advancing analytical methodologies for synthetic molecules. Join a motivated and experienced team where you will be the analytical leader for life-changing oligonucleotide projects from early development through to commercialization.

• Lead the end-to-end analytical development for synthetic molecule projects, specifically focusing on oligonucleotides, driving them from early development to commercial launch.

• Define and implement phase-appropriate control strategies for both oligonucleotide drug substances and drug products.

• Coordinate comprehensive analytical activities, including generating physical/chemical data and ensuring timely delivery and quality documentation.

• Develop, improve, and validate essential analytical test methods or other analytical controls in compliance with ICH guidelines.

• Act as the central analytical point of contact, effectively collaborating with cross-functional stakeholders, particularly drug substance process development and manufacturing.

• Author and compile necessary analytical documentation for regulatory submissions, including IND and NDA.

• Ensure meticulous adherence to cGMP, safety, and regulatory requirements in all internal and external laboratory work.

• Coach and mentor technicians and junior scientists on project work, fostering technical growth within the team.

You are an experienced and dynamic analytical scientist ready to take on a leadership role in a fast-paced environment. You possess the deep technical knowledge to drive complex projects and a proactive mindset to collaborate effectively.

• You hold a Master's or Ph.D. in Chemistry, Pharmacy, or a related field, paired with at least three years of professional experience in analytical development for oligonucleotide drug substances and products.

• You possess in-depth knowledge of oligonucleotide chemistry, covering synthesis, purification, and detailed characterization.

• You are an expert user of key analytical techniques such as HPLC, UPLC, and Mass Spectrometry (MS) specifically for oligonucleotide analysis.

• You have proven experience in developing, validating, and implementing ICH-compliant analytical methods.

• You are proficient in conducting degradation and stability studies for oligonucleotides, including forced degradation and impurity profiling.

• You have excellent communication, collaboration, and influencing skills, with the ability to confidently work across interdisciplinary and global teams.

• You possess digital acumen to support transformation initiatives, with familiarity in statistical analysis of analytical data being advantageous.

Ready to bring your unique qualities to Roche and make an impact? Apply now and join us in our mission to shape the future of healthcare.

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an Equal Opportunity Employer.