Senior Research Associate, In Vivo Pharmacology

Institute of Pharmacology and Toxicology

Senior Research Associate, In Vivo Pharmacology (Immuno-Oncology %

Start of employment Immediate start or to be mutually agreed

The group of Prof. Schwank is working on translational genome editing and cell-based therapies. We are seeking an experienced Research Associate %) to drive the in vivo components of a translational research program developing in vivo CAR T cell therapies based on RNA–lipid nanoparticle technology.

The successful candidate will independently execute and analyze preclinical studies in humanized and syngeneic tumor models, contributing directly to milestone delivery within a translational research program.

Your responsibilities

You will work closely with the Molecular Biology and RNA-Delivery teams to produce milestone-ready, in vivo da-tasets demonstrating in vivo CAR-T generation and antitumor activity in humanized and syngeneic models. The role combines hands-on animal experimentation, sample processing, and immunological analysis. You will be responsible for planning and executing tumor studies in humanized and syngeneic mouse models as well as per-forming follow-up analyses such as flow cytometry, cytokine profiling, and histological readouts.

Your profile

Candidates may come from various educational paths; relevant combinations of education and experience are equally valued. The candidate has at least a

• MSc in Biology, Biotechnology, Immunology, Pharmacology, or related field, with more than 3 years of relevant experience, or
• BSc in Life Sciences with more than 5 years of relevant experience.
• Extensive hands-on experience with mouse handling, including NSG or other immunodeficient strains.
• Proficiency in liquid (e.g. NALM-6) and solid tumor studies.
• Robust expertise with intravenous (IV), intraperitoneal (IP) and subcutaneous (SQ) injections of laborato-ry rodents.
• Strong tail vein intravenous dosing expertise is required.
• Demonstrated ability to perform flow cytometric experiments including sample preparation, staining, and basic data analysis.
• Experience with tumor immunology, immune-cell isolation, and ex vivo functional assays.
• Valid FELASA B/C or LTK 1/2 animal license (or equivalent).
• Strong organizational skills, attention to detail, and ability to work autonomously within project time-lines.
• Excellent record-keeping and data management skills; able to compile results for internal reports.
• Familiarity with RNA or nanoparticle-based therapeutics is a plus.
• Experience with longitudinal imaging and biodistribution studies is a plus.
• Prior exposure to GLP-like preclinical documentation or biotech environments is a plus.

Information on your application

Please apply with a single PDF (CV, brief cover letter) to Dr. Andreas Reichmuth. Applications will be reviewed on a rolling basis.

What we offer

Work-Life Balance

• Flexible working models (such as part-time positions, mobile working, job-sharing)
• Childcare at the kihz foundation of UZH and ETH

Learning and Development

• Wide range of continuing education courses of UZH and the Canton of Zurich
• Language Center run jointly with ETH Zurich

Food

• Food and drinks at reduced prices in the UZH cafeterias
• Lunch-Check-card with UZH contribution

Healthcare

• Special conditions on the Academic Sports Association ASVZ
• Free seasonal flu vaccinations
• Rest and relaxation at the quiet room in the university tower

Discounts

• Private traffic: Carsharing, rent a vehicle, parking space
• Digitalization: Hardware, software, mobile phone subscriptions
• Special conditions on hotel reservations

Conditions of Employment

• Policies of the UZH
• Most UZH staff are employed according to public law

International Services

• Support for people from outside Switzerland

Campuses

• Campuses Zurich City, Zurich Irchel, Oerlikon and Schlieren
• Sites Zurich West, Old Botanical Garden, Botanical Garden and Lengg

Location
Institute of Pharmacology and Toxicology

Winterthurerstrasse 190, 8057 Zürich, Switzerland

Further information
Questions about the job

Andreas Reichmuth

Postdoc

Working at UZH

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer

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