Scientist- Mouse Genetics

Vor 2 Tagen

Basel, Basel-Stadt, Schweiz Gi Group Vollzeit

For our client Hoffmann-La Roche, we are looking for an experienced

Scientist- Mouse Genetics and Outsourced breeding Management

  • Start Date:
    ASAP (latest
  • Duration:
    1 year
  • Workload:
    100%
  • Location:
    Basel
  • Home Office:
    No

About the Role

The ideal candidate brings deep expertise in the generation and validation of sophisticated transgenic mouse models. You will act as a strong advocate for the 3Rs (Replacement, Reduction, Refinement), driving optimized breeding strategies that ensure animal welfare, genetic stability, and scientific excellence.

In this highly cross-functional role, you will serve as the key interface between external breeding partners, internal vivarium operations, and therapeutic area teams — turning complex genetic concepts into robust, well‑characterized experimental cohorts that support drug discovery and development.

Tasks & Responsibilities

  • Provide high-level oversight of external
    CROs
    and internal breeding facilities to ensure operational excellence.
  • Develop and implement optimized
    breeding strategies
    focusing on quality, timelines, cost efficiency, and genetic stability, aligned with the 3Rs.
  • Serve as primary point of contact for
    external vivarium managers
    , resolving issues such as phenotype drift or health status deviations.
  • Act as internal expert for the
    generation of new mouse lines
    using modern genome engineering techniques.
  • Define and standardize
    official nomenclature
    for newly generated lines in alignment with
    MGI
    and international guidelines.
  • Maintain detailed records of
    genotyping and molecular validation data
    (e.g., NGS, Southern blot, qPCR).
  • Monitor
    health and welfare
    of experimental cohorts, define humane endpoints, and support assessment of unexpected phenotypes.
  • Develop and implement
    housing and care standards
    for contract‑bred animals at partner facilities.
  • Collaborate with therapeutic area experts to support initial
    phenotypic characterization
    and evaluate model utility.

Your Qualifications

  • PhD
    in Genetics, Molecular Biology, Biotechnology, or related field
  • 3+ years
    hands-on experience in mouse genetics and colony management
  • Familiarity with
    FELASA guidelines
    and animal welfare legislation
  • Proven track record in
    generating mouse models
  • Strong
    project management skills
    and ability to manage multiple external vendor relationships
  • Fluent
    English
    (written & spoken); German is an advantage

If this opportunity resonates with your background and career goals,
apply today
and become part of an innovative research environment driving the next generation of therapeutic solutions.

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