Senior Director, Clinical

Do you have experience leading complex clinical operations and biopharma diagnostic programs across multiple stakeholders and geographies? Can you bring structure, adapt quickly, and make a measurable impact on how large, strategic studies are delivered?

If this sounds like you and you are driven by purpose, join SOPHiA GENETICS as our new
Senior Director, Clinical and Biopharma Operations
, and enable us to make a positive impact on the outcomes for cancer and rare disease patients worldwide.

Enjoy the flexibility of a hybrid work schedule allowing 2 days PW home working, collaborating closely with colleagues in our Rolle, CH corporate office.

Our Mission
We believe there is a smarter, more data-driven way to make decisions in healthcare and our cloud-native AI powered SOPHiA DDM Platform makes that vision a reality on a daily basis. You will have direct input to our mission to democratize data-driven medicine for the ultimate benefit of cancer and rare disease patients across the globe.

Your Mission
As our
Senior Director, Clinical and Biopharma Operations
, you will play a pivotal role in orchestrating the end-to-end delivery of our flagship multimodal real-world evidence efforts as well as our portfolio of Biopharma diagnostics projects, in collaboration with leading biopharma partners. Working closely with Data Sciences, Tech, Biopharma, Product and Clinical teams, you will ensure seamless operational execution, robust data delivery, and pharma-grade quality across all programs. You will lead the design and implementation of scalable study operations, site engagement approaches, and cross-functional ways of working that enable predictable, high-impact outcomes.

The value you add
Lead Delivery of Strategic Portfolio of BioPharma-partnered Studies:

• Take overall operational accountability for large-scale multimodal real-world evidence efforts in collaboration with our pharma partners
• Oversee the portfolio of Biopharma Dx projects, from pilots to larger diagnostic collaborations, ensuring timelines, scope, and revenue commitments are met
• Lead, coach and develop an established global team of colleagues across Clinical and Biopharma Operations

Optimize Clinical & Biopharma Operations & Processes:

• Design and continuously improve end-to-end study workflows, from feasibility and site selection through activation, data collection, and site closure
• Implement scalable operating models and shape how we engage with leading academic and clinical sites across our network of over 800 institutions globally
• Act as a credible, independent counterpart to pharma partners, ensuring transparent communication, alignment on expectations, and smooth governance

Drive Study Performance, Data Quality & Analytics Interface:

• Lead key operational performance metrics (e.g., site activation velocity, patient recruitment, data completeness and quality)
• Partner closely with Data Science to ensure data curation, quality checks, and analytics are tightly linked to site operations and study design

Requirements

• Advanced degree in life sciences, medicine, pharmacy, or related field; additional certifications in clinical research (e.g., GCP, ACRP, PMP or equivalent) are a strong plus
• 10+ years' experience in clinical research/clinical operations within pharma, biotech, medtech and/or CRO environments, including responsibility for end-to-end study delivery
• 5+ years in people management, with a track record of developing and coaching high-performing, early-career talent
• Demonstrated experience leading complex, multicenter and/or international clinical studies and managing diverse project portfolios simultaneously
• Ability to build strong relationships with external stakeholders (e.g., investigators, site teams, pharma partners) and internal cross-functional teams (e.g., data science, product, tech)

Benefits
You will be joining an organisation with the patient at the heart of every decision and action, driven by purpose as we pursue exponential growth.

Business recognition and accolades include:

• World's most innovative companies (Top 10)
• World's smartest companies (Top 50)
• 100 Best Places to Work in Boston
• Top 10 European Tech Startup
• Top 10 European biotechs startup to watch
• Top 25 East-Coast Biotech to watch

Our benefits package is comprehensive, but varies internationally in-line with local standards and laws. You can discuss a full breakdown with us, but as a brief overview:

Sickness and Accident coverage through Helsana

• Meal Vouchers at 90CHF PM with our partner cafeteria
• A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit/snacks
• Free parking in an easy to access location
• A strong social committee whose purpose is to make SOPHiA GENETICs both enjoyable as well as rewarding
• As our global HQ, you'll have direct interaction and exposure to senior leadership and our executive team locally

Our DNA
Like the strands of DNA itself, SOPHiA GENETICS and the team are deeply interconnected and reliant on each other to deliver. There are common threads across the team. Things that bind us together. Those things are Relentless Curious; Resilient & Nimble and Fearlessly Adventurous

Our Virtues
At SOPHiA GENETICS we established our 7 Virtues to clarify how our principles show up each day through action. We Decide; We Do; We Collaborate; We Innovate; We Empower; We Adapt and We Learn.

At the centre of our Virtues is our Mantra, We Care, which provides a constant reminder of the compassionate, benevolent, and hopeful nature of our mission and how it should be threaded through each of our Virtues and everything we do. Learn more about our DNA and Virtues on our Careers portal

The Process
We use the power of AI to help our partners make decisions. If you're utilising AI in your search and application process, why not use some of these prompts, or read our AI guide.

'What impact can I expect to have on the world by working at SOPHiA GENETICS?'

'I have an interview with SOPHiA GENETICS. What should I know before I meet with them?'

'I am a *job title* - What can SOPHiA GENETICS offer my career?'

Apply now with your CV and any supporting information.

Suitably qualified candidates will be invited through an interview and screening process where you will speak with members of our Talent Acquisition Team, the hiring leader alongside key colleagues and stakeholders from across the business. If you need additional support for accessibility, please contact our TA team for assistance.

We appreciate the value external partners can bring, but we operate a direct-hiring model and we are not looking to utilise agency support at this time. All hiring is controlled by Talent Acquisition, potential partners should liaise through TA and not our hiring teams please.
Starting Date: ASAP; H1 2026

Location: Rolle, CH; Hybrid with occasional international travel

Contract: Full time, Permanent