Research Scientist Ii

Research Scientist II (80-100*)

600 scientists working on 340 discovery programs in 8 disease areas focusing on 90 new molecular entities makes Novartis a premier place to develop your career as a Research Scientist.

The Translational Immunology group within the Translational Medicine/Preclinical Safety Department in Basel, Switzerland is looking for a highly motivated scientist to join our interdisciplinary team.

Our group supports all phases of the drug development from target validation, lead optimization, clinical profiling, drug registration and beyond. We focus on the safety assessment of compounds aiming to de-risk potential immunosafety liabilities prior to human studies and to elucidate the mechanistic basis of immunotoxicities observed in either non-clinical or clinical studies

The Research Scientist will support in vitro experimentation using preclinical models and samples derived from clinical trials. The studies will utilize state-of-the-art technologies and will provide an ideal environment for professional development while contributing to the development of safe and efficient medicines for patients in need.

Your responsibilities:

- Use a variety of complementary methods and readouts, in a variety of functional in vitro and ex vivo human and/or animal immune system assays, to assess the safety and efficacy of drug development compounds.
- Perform the isolation, handling, culturing (days to weeks) and differentiation of primary leukocytes from different tissues and different species (human, rat, mouse, non-human primate etc.).
- Perform technical procedures necessary to execute a range of in vitro cell biology techniques (e.g., flow cytometry, multiplex ELISA, live cell imaging, etc.) in the course of conducting functional immune system assays (e.g., Fc effector function assessment, immune cell activation assays, cytokine release assays, immunophenotyping, etc.).
- Data analysis, biostatistics and graphical representation of data for reports and presentations. Handling of large, multi-parametric datasets is advantageous.
- Assist in the preparation of study protocols, reports and presentations, and has the ability to communicate results with large and small cross-functional teams.
- Provide quality testing, result verification while displaying good scientific judgement, and communicate results and interpretations in an accurate and timely manner.
- Display competence in the use of Preclinical Safety electronic data collection systems (e.g., Electronic Lab Notebook (ELN)).
- Assist in method development and validation of new methodologies and instrumentation as needed.
- Interact in cross-functional and cross-divisional teams supporting projects spanning our entire drug development pipeline

**Commitment to Diversity & Inclusion**:

- Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve._

**Minimum requirements**

What you’ll bring to the role:
Essential:

- Bachelor or master’s degree in immunology, cell biology or Medicine
- 3-5 years’ experience working in a laboratory in Academia or in the pharmaceutical industry
- Proficient in a variety of cell biology laboratory methods
- Fluency in English with the ability to communicate data and ideas within large and small teams
- Familiarity handling large, multiparametric, data sets for reports and presentation (Bioinformatics experience would be advantageous)

Desirable:

- Ability to learn and combine new techniques and concepts to perform exploratory activities at risk
- Strong motivation and ability to work independently, good record keeping with an aptitude to work collaboratively within different cross-functional teams
- Scientific curiosity, initiative, commitment, flexibility, and good organizational skills.

Why Novartis?
769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working. We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying

Imagine what you could do here at Novartis

**Division**

NIBR

**Business Unit**

Translational Medicine

**Country**

Switzerland

**Work Location**

Basel

**Company/Legal Entity**

Novartis Pharma AG

**Functional Area**

Research & Development

**Job Type**

Full Time

**Employment Type**

Regular

**Shift Work**

No

**Early Talent**

No