Phd Position in Computer-aided Drug Design of Carbohydrate Mimics
Vor 3 Tagen
**Project Overview**
**Collectin-11** is a pattern recognition receptor that initiates the lectin pathway of complement activation-an essential component of innate immunity. Beyond its role in pathogen defense, collectin-11 contributes to **sterile inflammatory responses**, such as ischemia-reperfusion injury, making it an attractive target for novel anti-inflammatory therapies.
**Your position**
**in silico design and molecular modeling of carbohydrate mimics** with the goal of developing potent and selective collectin-11 antagonists. These compounds will be synthesized and tested by experimental collaborators within our team. The project involves techniques such as
**molecular dynamics simulations, structure-based drug design (docking, scoring, QSARs), free energy calculations**,
**cheminformatics workflows, and machine learning**.
**Your profile**
- A Master's degree (or equivalent) in pharmaceutical sciences, chemistry, computational biology, bioinformatics, or a related field.
- ** Excellent understanding of structural biology and molecular interactions**, particularly in the context of protein-ligand recognition.
- Excellent understanding of structural biology and molecular interactions
- Previous experience with **modeling of carbohydrates and their binding proteins** is a plus.
- modeling of carbohydrates and their binding proteins
- Practical knowledge of molecular modeling tools and techniques (e.g., docking, MD simulations, FEPs, QM/MM methods).
- Programming or scripting proficiency (e.g., Python, Bash) is highly desirable.
- Strong problem-solving, analytical, and communication skills.
- Enthusiasm for interdisciplinary collaboration and innovation.
**We offer you**
**Why Basel?**The **University of Basel**-founded in 1460-is Switzerland's oldest university and a globally recognized research institution with exceptional strength in the life sciences. Situated in the center of **Europe's premier pharmaceutical and biotech hub**, Basel is home to leading companies in the field, and numerous cutting-edge startups, offering unique exposure to both academic excellence and industrial innovation.
- A fully funded PhD position (Swiss National Science Foundation) of total duration of 4 years
- Access to high-performance computing resources and state-of-the-art modeling tools
- A collaborative and intellectually stimulating research environment
- Opportunities for advanced training, international conferences, and networking
- An inclusive university in a vibrant, international city
**Application / Contact**
- A motivation letter
- Curriculum vitae
- Academic transcripts
- Contact information for at least two academic referees
Applications will be reviewed on a rolling basis until the position is filled. Preferred starting date is **August 1, 2025**.
Apply
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