Postdoctoral Researcher in Neurodegenerative Diseases

**Department of Quantitative Biomedicine**
**Postdoctoral researcher in neurodegenerative diseases 100 %**: Start of employment by agreement

The Department of Quantitative Biomedicine combines biomedical research, with biotechnology, and computational biology to develop the foundations of next generation precision medicine. Within this environment, we are a research group aiming to understand the pathogenic mechanisms leading to two major neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
For more information please see; Polymenidou Lab

**Your responsibilities**:
This senior postdoctoral position includes supervision to PhD and Master students, scientific presentations, manuscript preparation and grant writing.

**Your profile**:

- A Ph. D. degree in neuroscience, cell biology, life sciences, biochemistry, or a closely related field. Prior postdoctoral experience is not essential but would be advantageous.
- The applicant should have substantial experience in cell culture, particularly in the culture and handling of human iPSCs, NSCs, neural cultures, and glial cultures. Experience with brain organoids would be a valuable asset but is not a requirement. Prior work with models of neurodegenerative diseases is advantageous.
- We seek an individual with exceptional organizational abilities, the capacity to operate independently, and a friendly, helpful, and open personality.
- iPSC cultures and neural differentiation experience. Immunofluorescent staining, imaging and data analysis.
- Live cell imaging is a plus.
- FACS and flow techniques and data analysis.
- Work with RNA and RNA seq prep (library prep, QC, etc).
- Basic RNA seq and single-cell RNA seq data analysis (extensive experience would be an advantage).
- Biochemistry techniques (cell and tissue processing, protein extraction and purification, western blot, IP, native protein analysis, etc).
- Molecular biology techniques (design of vectors, molecular cloning, PCR, plasmid preparation, and analysis).
- Lentiviral vector preparation (LV prep, titration, handling).
- Cell and developmental biology knowledge.
- At least basic neuroscience and CNS anatomy knowledge.
- Experience with image and data analysis. Coding in R is an advantage but not required. General knowledge of the Office package and Google docs is required.
- Proficiency in spoken and written English is required.

Applications will be considered on a rolling basis until the position is filled. Employment start date immediately or to be mutually agreed.

**What we offer**:
**Work-Life Balance**
- Flexible working models (such as part-time positions, mobile working, job-sharing)
- Childcare at the kihz foundation of UZH and ETH

**Learning and Development**
- Wide range of continuing education courses of UZH and the Canton of Zurich
- Language Center run jointly with ETH Zurich

**Food**
- Food and drinks at reduced prices in the UZH cafeterias
- Lunch-Check-card with UZH contribution

**Healthcare**
- Special conditions on the Academic Sports Association ASVZ
- Free seasonal flu vaccinations
- Rest and relaxation at the quiet room in the university tower

**Discounts**
- Private traffic: Carsharing, rent a vehicle, parking space
- Digitalization: Hardware, software, mobile phone subscriptions
- Special conditions on hotel reservations

**Conditions of Employment**
- Policies of the UZH
- Most UZH staff are employed according to public law

**International Services**
- Support for people from outside Switzerland

**Campuses**
- Campuses Zurich City, Zurich Irchel, Oerlikon and Schlieren
- Sites Zurich West, Old Botanical Garden, Botanical Garden and Lengg

**Location**:
**Department of Quantitative Biomedicine***:Winterthurerstrasse 190, 8057 Zürich, Switzerland

**Further information**:
**Questions about the job**:
**Dr. Takayuki Yasunaga**
- Lab Manager

**Working at UZH**: