Associate (Director) Principal Biostatistician

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

The Biostatistics and Research Decision Sciences (BARDS) organization has a proud record of providing comprehensive analytical and methodological expertise to support our company’s strategic goals. Our quantitative scientists aspire to maintain the highest quality output while adopting the most efficient and effective scientific and operational procedures that will promote breakthrough innovation, collaboration and professional activity.

The BARDS organization has established in Europe its Center of Excellence supporting HTA dossiers. Our statisticians and statistical programmers collaborate with multiple functional areas across the company and with our local affiliates to ensure that the clinical trial data representing our products is characterized properly in these dossiers, and to develop innovative statistical approaches to novel problems in the HTA space.

Key responsibilities for the position

Provides statistical leadership and support to projects in the BARDS HTA (Health Technology Assessment) Statistics group, including HTA submissions.

Interacts with multidisciplinary scientists, company subsidiary project leads and Late Development Statisticians to support HTA submissions

Designs, develops and evaluates tools and methods for HTA evaluations

Gives input to VEST (Value Evidence Sub Team) as a statistical representative and may contribute to VEST meetings

**Primary activities for the position**:
Leads and provides statistical support to the cross-functional teams preparing HTA submissions

Plans and executes independently on the ongoing HTA evaluations, including analysis and interpretation of HTA results. Ensure that project deliverables meet analysis and submission requirements

Collaborates with Statistical Programming lead to implement methodologies and ensure high quality deliverables for HTA submissions

Leads the preparation of the written reports to effectively communicate results of HTA evaluations to the outcomes research and company affiliate teams

Designs, develops and applies HTA methods, processes and standard tools

Provides responses for queries from HTA agencies related to statistical analyses and methodological rationale

Evaluate appropriateness of available software for planned analyses and ascertains needs for potential program development of novel statistical methodology.

May guide junior staff or contractors in functional activities within a project

**Qualifications**:
**Education and Minimum Requirement**:
PhD or equivalent degree in statistics/biostatistics or a related discipline with a minimum of 3 years relevant work experience, Master's with a minimum of 6 years relevant work experience, or bachelor’s with 10 years relevant experience

**Required Skills and Experience**:
Good knowledge of biostatistical methodologies and experimental design, including meta-analyses and time to event methodologies. Understanding of data management and clinical concepts applied to drug development within the pharmaceutical industry.

Team oriented, strong collaboration skills and ability to work effectively across cultures.

Must also demonstrate the ability to learn, be proactive and motivated, and consistently focus on details and execution.

Project management. proficiency

Strong communication skills, ability to work with staff with different functional background.

**Preferred Skills and Experience**:
Strong knowledge of computer systems and clinical databases systems in a statistical environment.

Experience in CDISC data standards (SDTM, ADAM)

Understanding of biology of disease and drug development.

Publication record in peer reviewed statistical/medical journals

THE COMPANY

Our company has had a presence in Switzerland since 1963. With a regional office and manufacturing/packaging facility, Lucerne is considered the center of operations. Approximately 1,000 people work collaboratively at the four Lucerne locations (Weystrasse, Citybay, Schachen and Kriens). A fifth location has been recently established in Zurich, aimed at accelerating the development and commercialization of many of our company’s medicines and vaccines, which supports our mission to save and improve lives around the world. The new location has a target date of 2021 for operational readiness.

We are proud to be certified as a “Top Employer Switzerland” and “Top Employer Europe” showing the company’s commitment to our employees and the community around us.

Zurich

The recently opened new location in Zurich focuses on accelerating research, data and commercialization of our medicines and vaccines.