Internship Opportunity Zampieri Lab

vor 16 Stunden


Basel, Schweiz The Biozentrum, University of Basel Vollzeit

Your position High-throughput drug screening has traditionally relied on 2D cell culture systems, which often fail to capture the structural and metabolic complexity of in vivo patient tumors. This project aims to overcome that limitation by extending our high-throughput metabolic fingerprinting platform into 3D cancer models such as spheroids and organoids. By combining untargeted metabolomics, high-content imaging, and computational modelling, we will systematically compare how 320 small molecules reshape metabolism in both 2D and 3D environments. The resulting dataset will reveal which drug-induced metabolic programs are shared between dimensional contexts and which emerge uniquely in physiologically relevant 3D systems. Ultimately, this work will generate a high-impact resource that improves mechanistic drug profiling and informs model selection across cancer research and drug discovery.In line with our and Uni Basel values (



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    Your position High-throughput drug screening has traditionally relied on 2D cell culture systems, which often fail to capture the structural and metabolic complexity of in vivo patient tumors. This project aims to overcome that limitation by extending our high-throughput metabolic fingerprinting platform into 3D cancer models such as spheroids and organoids....


  • Basel, Schweiz Universität Basel Vollzeit

    The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 800 employees, the...


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  • Basel, Schweiz Universität Basel Vollzeit

    The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and disease and to develop pioneering therapies benefiting the lives of patients in areas of unmet need. With more than 70 research groups and 900 employees, the...