In vivo Research Scientist

vor 2 Wochen


basel, Schweiz Novartis Vollzeit

Job Description Summary Location: Basel, SwitzerlandFull time, onsite, #Li-onsiteAt Novartis, we are reimagining medicine to improve and extend people's lives. We use innovative science and technology to address some of society's most challenging healthcare issues. We discover and develop breakthrough treatments and find new ways to deliver them to as many people as possible.As an In-vivo Research Scientist in the Immunology Disease Unit in Biomedical Research, you will play a pivotal role contributing to and being responsible for conducting a variety of complex research activities under the guidance of the lab head to help achieve the objectives of the immunology program.Job Description Key responsibilities of the role will include designing, overseeing, and conducting in vivo studies in rodents focused on autoimmune diseases or mechanistic PK/PD models. This involves tasks such as dosing, monitoring, scoring, and collecting samples. In addition, key responsibilities include performing ex vivo readouts such as cytokine and biomarker profiling, flow cytometry and histological evaluations to complement in vivo findings. The Research Scientist also analyzes experimental data, interprets findings, proposes innovative strategies to advance research, and maintains meticulous experimental records. Additionally, you will be responsible for prioritising tasks effectively, meeting project deadlines, and ensuring compliance with safety protocols and regulatory standards. Minimum Requirements: What you will bring to the role Your Profile: ·       Completed apprenticeship as a laboratory technician or Bachelor/Masters in biochemistry, biology, molecular biology, life sciences, or a related field ·       Minimum 2-3 years relevant lab based work experience in an industrial or academic setting, preferably in immunology research with in-vivo research as a focus LTK I or equivalent animal research qualification is essential. Research Techniques and Expertise: Proficiency in mouse models and handling techniques, including blood sampling, oral gavage, injections (IV/IP/ID/SC), perfusion, organ harvesting, anesthesia, and euthanasia Proficiency with planning and running mechanistic PK/PD in vivo models and / or disease models related to immune indications Proficiency in cellular immunology methods and ex vivo readouts such as ELISA, multiplex assays. Multicolour flow cytometry and qPCR experience would be an advantage Experience working with human cell



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