Pharmaceutical Research Scientist

Vor 5 Tagen


Basel, Basel-Stadt, Schweiz F. Hoffmann-La Roche Gruppe Vollzeit

At F. Hoffmann-La Roche Gruppe, we're passionate about transforming patients' lives through medical solutions. We believe it's urgent to deliver high-quality research today, while developing innovations for the future.

The Position

We're seeking a highly motivated postdoctoral fellow to join our Immunology Discovery group in Basel, Switzerland. The successful candidate will investigate the molecular pathways driving human alveolar cell regeneration and function under disease conditions.

Key Responsibilities:

  • High-throughput culture of human alveolar and airway organoids
  • Investigating disease-relevant perturbations to identify conditions that recapitulate the disease molecular state
  • Phenotypic and molecular characterization using techniques such as immunofluorescence, flow cytometry, and single-cell RNA-sequencing (scRNA-seq)
  • Using pharmacological modulators to understand pathways involved in alveolar cell regeneration and differentiation
  • Investigating how modulating identified signaling pathways can impact the function of alveolar progenitor cells under disease conditions

Qualifications:

  • PhD in Molecular Biology, Cell Biology, Developmental Biology, Pharmacology, or a related field
  • Strong background in cell signaling, particularly Wnt pathways, and experience with organoid culture systems
  • Proficiency in high-throughput screening techniques and data analysis is desired
  • Experience with genetic engineering and iPSC technology is desirable
  • Proficiency in computational analysis and data interpretation is highly desired
  • Excellent problem-solving skills and the ability to work independently and collaboratively in a multidisciplinary team


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