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Process Chemistry Leader
vor 2 Wochen
Company Overview
Roches Synthetic Molecules Technical Development department is a key contributor to the development of innovative pharmaceuticals. With a focus on process chemistry and catalysis, we are seeking an experienced leader to join our team as a Section Head of Process Chemistry & Catalysis.
We bring a broad range of experience across drug substance and drug product, collaborating closely with key partners in Research and Early Development, commercial manufacturing, and other technical functions. Our goal is to develop safe, robust, and sustainable commercial manufacturing processes for synthetic drug substances.
Responsibilities:
- Leading a Process Chemistry Section with approx. 15 co-workers (scientists and associates) according to the Roche Leadership Commitments.
- Supporting and delivering a portfolio of projects with focus on tides (oligonucleotides and peptides) by assigning resources, setting priorities, and providing sound judgment for decision making and problem solving.
- Fostering the development of cost-efficient and robust processes and process understanding by using state-of-the-art science and methodologies to enable lean manufacturing.
- Providing scientific and technical input to project teams and further developing your section towards a lean and agile organization.
- Supporting Roches regulatory submissions by applying principles of Quality by Design to drug substance development and corresponding documentation while ensuring compliance with quality and regulatory requirements.
- Actively supporting the departmental digitalization and M&S efforts as well as contributing in defining the department's future technical and regulatory strategies and concepts.
Requirements:
- A PhD degree in organic chemistry with at least 10 years' experience in process chemistry for synthetic molecules (including small molecule, oligonucleotides, and peptides), spanning the entire range from route design, process development, process characterization, and process transfer to commercial manufacturing.
- Excellent people leadership skills and a strong ability to act visionary and be the catalyst, mentor, and architect for teams and members. Profound experience as matrix leader of complex projects.
- Excellent knowledge in oligonucleotide and peptide chemistry and extensive experience in working with external collaboration partners in Europe, US, and Asia.
- Comprehensive understanding of sustainable process development and how to implement green chemistry concepts into manufacturing processes and excellent understanding of scientific methodology, principles of data integrity, and good documentation practices.
- Excellent communication skills and a strong ability of building and maintaining constructive and effective relationships with stakeholders as well as strong collaboration and team-building skills.