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Cell Therapy Research Manager

vor 2 Wochen


Basel, Basel-Stadt, Schweiz Karlstad University Vollzeit
Job Title: Senior Scientist (T Cell Therapy Development)

About the Team

We are a cross-functional team dedicated to advancing cutting-edge immunotherapies from conceptualization to early-phase clinical trials. Our team consists of experts in immunology, multicolor flow cytometry, immune assays, genome-editing technologies, and in vivo experimental design and execution. We are seeking an experienced and innovative Senior Scientist to join our team and contribute to the development and characterization of T cell-based therapies for EBV-associated cancer.


Duties and Responsibilities
  1. Design and optimize strategies for developing T cell-based therapeutic products;
  2. Lead preclinical studies to evaluate T cell function, persistence, and efficacy;
  3. Develop and execute multicolor flow cytometry panels to assess immune cell phenotypes and functions;
  4. Design and perform immune assays, including cytokine profiling, cytotoxicity assays, and proliferation assays;
  5. Utilize genome-editting tools to engineer transgenic TCR libraries for enhanced therapeutic potential;
  6. Analyze experimental omics data;
  7. Contribute to the preparation of regulatory documents and grant applications;
  8. Support technology transfer processes for manufacturing T cell therapy products;
  9. Work collaboratively with multidisciplinary teams;
  10. Mentor junior scientists and research associates;
  11. Analyze complex datasets to inform decision-making and improve product development strategies;
  12. Prepare high-quality scientific presentations, reports, and publications.

Requirements

We require a PhD in Immunology, Cellular Biology, or a related field, preferably with postdoctoral experience. A proven track record in T cell therapy research and development, extensive hands-on experience in immune cell assays and multicolor flow cytometry, proficiency in CRISPR/Cas9 and library design, genomics and/or transcriptomics data analysis, and experience with clinical translation of cell-based therapies are highly desirable.