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Senior Biotechnology Engineer
vor 1 Woche
About Adaptyv
At Adaptyv, our cutting-edge cloud lab empowers protein designers to validate their proteins seamlessly. We're developing advanced molecular biology workflows, assay automation, and software infrastructure to simplify protein engineering for our users.
The Role
We seek an experienced scientist to join our Biology Team, specializing in high-throughput DNA synthesis, enzymatic DNA synthesis, and oligo pool assembly. You will play a pivotal role in designing and optimizing molecular biology workflows, integrating them into our Foundry to accelerate synthetic biology and protein engineering applications.
Responsibilities
- Develop and automate high-throughput DNA synthesis and assembly workflows, including enzymatic DNA synthesis, Gibson, Golden Gate, PCR-based methods (e.g., PCA, overlap extension), and oligo pool assembly for large-scale DNA library construction.
- Optimize and scale DNA synthesis pipelines using state-of-the-art automation equipment, liquid handlers, and microfluidic platforms.
- Design and implement validation assays for DNA constructs, including sequencing-based quality control (NGS: Illumina, Nanopore) and functional expression assays.
- Integrate DNA synthesis and assembly workflows into our Foundry, working closely with the Software Team to enable seamless automation, tracking, and data analysis.
- Support protein engineering efforts by designing and assembling large variant libraries, optimizing constructs for expression and function in collaboration with our ML Team.
Qualifications
- Bachelor's, Master's, or Ph.D. in Molecular Biology, Biotechnology, Bioengineering, Chemical Biology, or a related field.
- A minimum of 2 years of hands-on experience in molecular biology, with a strong focus on DNA synthesis, assembly, and automation.
- Experience with liquid handlers, robotic automation, and high-throughput molecular biology workflows.
- Proficiency in Python for data analysis, automation integration, and experiment design.
- Strong understanding of NGS-based validation, enzymatic DNA synthesis, and large-scale DNA processing.
- Nice to have: Experience with cell-free protein synthesis, protein-protein interactions, or enzymatic activity assays.
- You thrive in a fast-paced startup environment, enjoy problem-solving, and are eager to develop and implement cutting-edge technologies.
