Postdoctoral Fellow in Nanoscale Cardiac Signalling

vor 2 Wochen

Bern, Schweiz Universität Bern Vollzeit

Institute for Physiology
Start of employment: 01.07.2024 or by agreement
Employment is fixed for 3 years

Calcium signaling in cardiac myocytes is highly sensitive to the nanoscale arrangement of proteins involved in cardiac excitation-contraction coupling. To improve our understanding of these relationships we have established a new multi-instrument super-resolution microscopy facility in the Institute of Physiology. This includes the latest MINFLUX technology that enables optical fluorescence imaging down to the single nanometer finally enabling truly molecular imaging. The project will focus on dissecting a newly discovered mechanism in cardiac calcium regulation termed "ryanodine receptor dispersion". The basis of this mechanisms is the molecular scale redistribution of ryanodine receptors leading to altered functional calcium release as a novel mechanism for the contractile regulation of cardiac myocytes [1]. To investigate this mechanism we have developed new ways to to correlate the nanoscale structure of protein arrangements and membrane systems with the physiology of calcium regulation in cardiac muscle by correlating live cell calcium and super-resolution protein distribution imaging [2]. The latest addition to our toolbox is MINFLUX imaging for molecular scale imaging of cardiac proteins [3]. The combined approach will be used to improve our understanding of cardiac dysfunction and loss of contractility to identify new treatment regimens for cardiac disease. We are looking for a well-trained and experienced researcher who will conduct and design experiments using our advanced imaging and analysis techniques

Tasks will include:

- Design and conduct experimental series with cardiac myocytes
- Design and conduct optical super-resolution imaging experiments
- Advanced image and statistical analysis of experimental data
- Scientific writing to the highest standard and compilation of high impact research publications
- Co-supervision of Masters and Doctoral students

**Requirements**:

- MD or PhD in a medical, biological or biophysical discipline with a suitable quantitative background
- experience as detailed below
- Good speaking knowledge of English or German

Experience should include some of the following areas:

- optical super-resolution imaging
- physiological calcium imaging in cardiac preparations
- image data analysis
- general biophysics/physiology training and expertise

We offer

How to apply

31 May 2024

Soeller Lab
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