Phd Position in Proteomics, Cell Biology and Cancer
vor 4 Wochen
We are recruiting a PhD student for an interdisciplinary project to study the regulation of neo-antigen presentation on cancer cells and extracellular vesicles (EVs) as a new possibility to treat/diagnose cancer.
Project
The major histocompatibility complex-I (MHC-I) plays a central role in immune regulation by presenting short peptides of cell-internally degraded proteins on the cell surface to immune-competent CD8+ T-cells. Nonsense-mediated mRNA decay (NMD) is an evolutionary conserved mechanism destroying aberrant mRNA. Somatic mutations accumulate in cancer cells where NMD removes non-functional mRNA. Thus, a large fraction of potential neo-antigens is not produced and presented on the surface of cancer cells. Known inhibitors of NMD could potentially revert this situation and trigger an immune response against cancer cells. Furthermore, MHC-I is abundantly present on EVs. EVs are known effectors of stroke, myocardial infarct or infections - symptoms occurring in hematopoietic stem cell disorders like myelodysplastic syndromes (MDS).
**Requirements**:
Who we are and what we offer
The position is available immediately for the duration of 3-4 years with a salary according to University of Bern guidelines.
How to apply
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